With 2-cyanopyridine as raw material,through hydrolysis,neutralization and complexation reaction,chromium 2-picolinate is prepared.By improving the reaction solvent,the complexation pH and the complexation temperature,some problems of chromium 2-picolinate are solved,for example the crystal size is too small and the fluidity is poor.After 2-cyanopyridine is dissolved in ethanol,sodium hydroxide aqueous solution is added,and the hydrolysis reaction happens in homogeneous phase,and the reaction time is reduced from 10 h to 1.5 h.The pH value is adjusted to 8.9 after the hydrolysis reaction,which makes complexation reaction occur easily.Complexation temperature is set to(50±2)℃,which is in favor of crystal growing bigger.The purity of chromium 2-picolinate prepared by this method is 99.8％,the max impurity is 0.04％,the total impurity is 0.12％,the crystal particles are uniform,the fluidity is good,the angle of repose is 31°,and the method makes it easy to mix uniformly in the process of pharmaceutic preparation.
organic synthesis chemistrychromium 2-picolinatetechnology improvementfluidityangle of repose
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