Correlation between the quality of Dianthi Herb(Dianthus chinensis L.)formula granule and characteristic map of decoction pieces
In order to establish the method of predicting the quality index of Dianthi Herb(Dianthus chinensis L.)formula granules based on the characteristic map of decoction pieces,the correlation between the quality of Dianthi Herb(Dianthus chinensis L.)formula granules and the characteristic map of decoction pieces was investigated.The chemical components of different medicinal parts in Dianthi Herb(Dianthus chinensis L.)raw materials were characterized by the characteristic atlas,the difference peak was defined,and the peak area ratio(α)of the difference peak to the total characteristic peak in the characteristic atlas of 15 batches of decoction pieces was calculated;At the same time,according to the national standard of Dianthi Herb(Dianthus chinensis L.)formula granules,the total flavonoids content,paste yield,extract and other indexes of Dianthi Herb(Dianthus chinensis L.)formula granules prepared by using the above 15 batches of decoction pieces were determined;Pearson correlation analysis method was used to analyze the correlation between α value in the characteristics of decoction pieces and the total flavonol content,paste yield and extract of formula granules,the corresponding regression model was established,and the quality parameters of six batches of Dianthi Herb(Dianthus chinensis L.)raw materials and formula particles with production scale were used for verification.The result shows that the relative peak area of vaccarin and saponarin in different medicinal parts in decoction pieces was different,and the α ratio of the total peak area of the two peaks was 0.45～0.83 in 15 batches of decoction pieces;Through Pearson correlation analysis,it is found that the total flavonoids content,paste yield and extract are significantly positively correlated with α value(P＜0.01),total flavonoids content is strongly correlated with α value,and paste rate and extract are strongly correlated with α value;According to the three regression models established according to the correlation,the R2 obtained is all greater than 0.7,and the model has a high degree of fitting.Through the verification of six batches of data,it is found that the relative standard deviation of the predicted value and the measured value is less than 15%,indicating that the model has a good accuracy.In this study,the α value in the characteristic map of raw materials can be used to preliminarily predict the index range of Dianthi Herb(Dianthus chinensis L.)formula granules,and can achieve source control of the quality of Dianthi Herb(Dianthus chinensis L.)formula granules,ensuring the controllability of the obtained formula granules quality.
chemistry of Chinese material medicaldecoction piecesformula granulecharacteristic mappeak area ratiocorrelationcontrollability
万方数据
维普
