Application of Chitosan Drug Delivery Systems in Tumor Treatment by Photodynamic Therapy
Photodynamic therapy(PDT)has become a research hotspot in tumor treatment due to its superi-or response and high efficacy in tumor killing.However,the low solubility,propensity to aggregate,lack of tar-get specificity,and limited treatment depth of photosensitizer(PS)have hindered the further clinical application of PDT.Chitosan(CS),a natural cationic polysaccharide,has excellent acid-base sensitivity,biosafety,biocom-patibility,and biodegradability,and becomes an ideal choice for drug delivery carriers.In this paper,we review the research and application progress of CS and its derivatives as PS drug delivery carrier from three aspects:nanoparti-cles,nanoliposomes,and nanohydrogels.Moreover,we summarize the biological functions of CS and its derivatives drug delivery systems in tumor treatment by PDT,such as targetability and immune adjuvant,and put forward research prospects,aiming to provide theoretical basis for the combined application of CS and PDT in tumor treatment.
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