Health Risk Ranking of Antibiotic Resistance Genes in Environment
The rapid emergence and dissemination of antimicrobial resistance(AMR)poses a significant threat to global public health.In addition to medical and animal husbandry,antibiotic resistance genes(ARGs)can spread and transfer to human pathogens in various environmental media,affecting human health.Identifying high risk ARGs in the environment is the foundation for effective environmental monitor and risk assessment of ARGs.In this paper,we summarized the research status of ARGs in the environment.Moreover,focusing on the plasmid-borne ARGs,we proposed a risk ranking framework for environmental ARGs,and conducted plasmid group analysis on environmental samples from pharmaceutical factory and breeding plant to form a risk ranking list.The results show that,based on four criteria,such as mobility of ARGs(co-existence with mobile genetic el-ements),plasmid type,prevalence in human pathogens,and pathogenic potential(co-existence with virulence factors),a total of 425 plasmid-borne ARGs are detected from environmental samples of pharmaceutical factory and breeding plant,including the highest risk rank Ⅰ 0 ARG,rank Ⅱ 2 ARGs,rank Ⅲ 33 ARGs,rank Ⅳ 89 ARGs,and rank V 301 ARGs,forming a risk ranking list for pharmaceutical factory and breeding plant.The high risk ARGs detected in this study provide theoretical and data support for monitoring environmental ARGs pollution and assessing population exposure health risks.
万方数据
维普
