Learning to use Office is the key point of students'experimental practices in College Computer Basics.As an introductory course,computer programming design is also particularly important.This study uses Python language for the program design in Office application based on two solutions namely Win32 COM components and Python function library.Both solutions are object-oriented and integrated with the loop structure,in which the program design and Office applications are combined organically,and the student's program design interest and power are enhanced.