Effect of Cynomorium songaricum Water Extract on Testicular Injury Induced by Cyclophosphamide in Mice
To study the effect of Cynomorium songaricum water extract on cyclophosphamide induced testicu-lar injury in mice.Twenty four Kunming mice were randomly divided into blank group,model group,treat-ment group and control group.The mice testicular injury model was induced by intraperitoneal injection of cyclophosphamide.The treatment group and the control group were treated with Cynomorium songaricum wa-ter extract(1.5 g/kg b.w.)and Jinkui Shenqi Pill(1.2 g/kg b.w.),respectively.The testicular index,sperm sur-vival rate,deformity rate,testicular tissue morphology and serum testosterone level of mice were measured.The results showed that the Cynomorium songaricum water extract could significantly increase the testicular index and spern survival rate of mice(P<0.05),significantly reduce the sperm deformity rate(P<0.05),further maintain the integrity of testicular tissue and seminiferous tubules,and increase the serum testosterone level.The level of SOD in mouse testis was significantly increased(P<0.05),and the level of MDA was significant-ly decreased,so it had good antioxidant function.In conclusion,the Cynomorium songaricum water extract has a certain improvement effect on the damage of mouse testis tissue induced by cyclophosphamide.