Changes of serum ferritin and the reaction of oxidative stress in patients with diabetic peripheral neuropa-thy with epalrestat treatment
Objective To observe the changes of serum ferritin and the reaction of oxidative stress in patients with diabetic peripheral neuropathy with epalrestat treatment.To explore the improve effect of oxidative stress and high ferritin in patients with diabetic peripheral neuropathy with epalres-tat treatment.Methods A total of 100 patients which were divided into observation group and control group 50 cases each group according to random number table method.In the control group were receiv-ing breviscapine 50mg,iv qd for two weeks,The observation group were additionally given epalrestat 50mg,oral tid for twelve weeks on the basis of the control group.And observed the levels change of Serum Ferritin (SF),serum superoxide dismutase (SOD),glutathione (GSH),malondialdehyde (MDA)before and after twelve weeks in two groups.Results The two groups after treatment,the se-rum MDA and SF contents were lower than those before therapy,The observation group was signifi-cantly lower than that of the control group(P <0.01);The levels of serum SOD、GSH increased after treatment in two groups,The observation group was significantly higher than that of control group(P<0.01).Conclusion Epalrestat can improve oxidative stress and high ferritin in patients with diabetic peripheral neuropathy.
Type 2 diabetesDiabetic peripheral nephropathyEpalrestatSerum ferritinOxida-tive stress
NETL
NSTL
万方数据
维普
