Treatment of breast cancer with NAC sparing subcutaneous gland resection and wrapped prosthesis node TiLoop patch reconstruction
Objective To investigate the advantages of the treatment of breast cancer by combi-ning subcutaneous gland resection of preserving nipple-areolar complex(NAC)with wrapped prosthe-sis and TiLoop patch reconstruction.Methods Seventy patients with breast cancer who were treated in the Department of Breast Surgery of Nanyang Central Hospital from May 2021 to December 2022 were randomly divided into observation group and control group,35 cases each.The observation group was treated with the combined treatment of subcutaneous gland resection of preserving NAC,wrapped prosthesis and TiLoop patch reconstruction.The control group was treated with the modified radical mastectomy treatment plan of removing breast tissue and its surrounding normal tissue.The clinical effects,postoperative complications,surgical indicators,neurotensin receptor 1(NTSR1),and chromogranin A(CgA)levels were compared between the two groups.Results The total effective rate of the observation group was 94.29％,higher than that of the control group(74.29％).The inci-dence of postoperative complications was 5.71％,which was significantly lower than that of the con-trol group(25.71％).The differences were statistically significant(P＜0.05).The intraoperative blood loss,operation time,postoperative extubation time,and hospital stay of the observation group were better than those of the control group(P＜0.05),while there was no significant difference in the positive rate of sentinel lymph nodes and hospital stay between the two groups.NTSR1 and CgA levels at 6 months after operation in the observation group were(15.9±3.4)ng/mL and(27.3±4.0)ng/mL,respectively,while those in the control group were(13.8±2.6)ng/mL and(35.1±6.2)ng/mL,respectively.The differences were statistically significant(P＜0.05).Conclusion The treat-ment of breast cancer by combining subcutaneous gland resection of preserving NAC with wrapped prosthesis and TiLoop patch reconstruction is a safe and effective surgical method for breast cancer.It can improve the clinical effect of patients,reduce postoperative complications,and improve neuroen-docrine function.It is worthy of clinical promotion and application.
Breast cancerNipple-areolar complexSubcutaneous gland resectionWwrapped prosthesisTiLoop patchNeurotensin receptor 1Chromogranin A
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