脓毒症相关性急性肾损伤研究进展
Advances in the study of sepsis-associated acute kidney injury
曾江维 1张梦新 1冯凯 1部璇 1李金玉 1张于 2白静1
作者信息
- 1. 华北理工大学附属医院重症医学科 河北唐山 063000
- 2. 唐山市人民医院重症医学科
- 折叠
摘要
脓毒症及其所导致的多器官功能障碍严重威胁着人类生命健康,急性肾损伤(AKI)是其常见并发症.脓毒症相关性急性肾损伤(SA-AKI)具有高发病率和高病死率的特点,是危重症医学领域亟待解决的热点问题.既往基于尿量和肌酐的诊断标准对SA-AKI早期诊断有一定的限制,新型生物标志物的发现弥补了其早期诊断不足的缺陷.尽管对SA-AKI严重性的认识和病理、生理机制的了解不断加深,针对其治疗的研究也取得了一定的成果,但尚缺乏确切有效的治疗方法,导致预后不佳.本文参阅相关文献数据,对SA-AKI的病理生理机制、治疗和预防综述如下.
Abstract
Sepsis and its associated multiple organ dysfunction pose a serious threat to human life and health,with acute kidney injury(AKI)being a common complication.Sepsis associated acute renal injury(SA-AKI)is characterized by high incidence rate and high mortality,which is a hot issue in critical care medicine.The diagnostic criteria based on urine output and creatinine in the past have certain limitations on the early diagnosis of SA-AKI,and the discovery of new biomarkers has made up for the shortcomings of its early diagnosis.Despite the deepening understanding of its severity and pathophysiological mechanisms,there is currently a lack of definite and effective treatment methods,leading to poor prognosis.At present,research on the treatment of SA-AKI has also achieved certain results.This article reviews the pathological and physiological mechanisms,treat-ment,and prevention of SA-AKI based on existing literature data.
关键词
脓毒症/急性肾损伤/病理生理机制/治疗Key words
Sepsis/Acute kidney injury/Pathophysiological mechanism/Treatment引用本文复制引用
基金项目
河北省博士后科研项目(2022)(B2022003041)
出版年
2024
NETL
NSTL
维普
万方数据