Diagnostic value of spiral CT spectral imaging in the pathological differentiation degree of colorectal canc-er
Objective To explore the accuracy of preoperative CT spectral imaging in predicting the pathological differentiation of colorectal cancer patients.Methods 82 patients with colorectal canc-er confirmed by preoperative colonoscopy or surgical pathology in Affiliated Hospital of North China University of Science and Technology from September 2019 to December 2022 were collected.Accord-ing to the pathological differentiation degree of colorectal cancer,they were divided into the moderate-ly and highly differentiated group(62 cases)and the poorly differentiated group(20 cases).GE Revo-lutionCT scanner was used to perform spectral imaging scan on the patients,and the single-energy CT values,iodine concentration(IC),water concentration(WC),and effective atomic number(Eff-Z)of the lesions in the arterial and venous phases at 40～140kev were measured and recorded.In addition,normalized iodine concentration(NIC)and spectral curve slope(λ)were calculated.Results In the ar-terial phase,the single-energy CT values of the poorly differentiated group at 40～140kev were higher than those of the moderately and highly differentiated group(P<0.05).The IC,NIC,andλof color-ectal cancer in the poorly differentiated group were also higher than those in the moderately and highly differentiated group(P<0.05).In the venous phase,the single-energy CT values of the poorly differ-entiated group at 40～130kev were higher than those of the moderately and highly differentiated group(P<0.05).Additionally,the IC,NIC,λ,and Eff-Z of colorectal cancer in the poorly differentiated group were higher than those in the moderately and highly differentiated group(P<0.05).Compared with the arterial phase,the single-energy CT values at 40～90kev and the combined prediction of spec-tral parameters IC+NIC+λ+Eff-Z in the venous phase had better performance in predicting the dif-ferent degrees of differentiation of colorectal cancer,with an AUC of 0.943.Conclusion Spectral CT imaging can effectively predict the differentiation degree of colorectal cancer before surgery,providing imaging evidence for clinicians.
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