Efficacy analysis of Huoxue Yangxin Decoction in the treatment of heart failure with reduced ejection frac-tion
Objective To investigate the efficacy of Huoxue Yangxin Decoction in the treatment of heart failure with reduced ejection fraction(HFrEF).Methods A total of 84 patients with HFrEF treated at the Ninth People's Hospital of Zhengzhou from January 2021 to January 2023 were selected as the study subjects.They were randomly divided into an observation group and a control group,with 42 patients in each group.The control group received oral sacubitril valsartan sodium tablets,dapagli-flozin,bisoprolol fumarate tablets,and spironolactone.The observation group was treated with self-designed Huoxue Yangxin Decoction in addition to the treatment given to the control group.Chi-square test was used to compare the clinical efficacy and adverse reactions between the two groups.Paired t-test was used to compare the left ventricular function indicators,serum myocardial marker levels,and 6-minute walk test levels between the two groups.Results(1)The total effective rate was 95.24％in the observation group and 80.95％in the control group after treatment(P＜0.05).(2)After treat-ment,the LVEF was(53.21±7.51)％and LVESD was(40.26±4.35)mm,LVEDD was(56.25±4.71)mm in the observation group,while in the control group,they were(45.13±2.17)％,(46.43±3.17)mm,and(60.23±4.36)mm,respectively.The difference between the two groups was statistical-ly significant(P＜0.05).(3)After treatment,NT-pro-BNP was(1954.52±319.82)pg/mL,Gal-3 was(9.28±1.42)ng/mL,IL-6 was(11.13±1.27)ng/L,and IL-33 was(40.51±2.14)ng/L in the ob-servation group,while in the control group,they were(2473.41±532.14)pg/mL,(10.49±1.81)ng/mL,(19.10±1.35)ng/L,and(48.84±2.72)ng/L,respectively.The indicators in the observation group were significantly lower than those in the control group(P＜0.05).(4)After treatment,the 6-minute walk test was(194.62±44.71)m in the observation group and(152.16±35.18)m in the control group,showing that the observation group was better than the control group(P＜0.05).(5)The to-tal incidence of adverse reactions was 4.76％in the observation group and 19.75％in the control group(P＜0.05).Conclusion Huoxue Yangxin Decoction can effectively improve the efficacy of HFrEF pa-tients,enhance cardiac function,reduce inflammatory response,and reduce the occurrence of adverse reactions.Combined with the"new quadruple therapy,"it is a feasible treatment plan integrating tra-ditional Chinese and Western medicine.
Huoxue Yangxin DecoctionHeart failureLeft ventricular ejection fractionCardiac function
万方数据
维普
