Effects of roflumilast combined with erigeron breviscapus on cognitive function,serum inflammatory me-diators,and oxidative stress indicators in patients with COPD
Objective To investigate the effects of roflumilast combined with Erigeron brevisca-pus freeze-dried powder on cognitive function,serum inflammatory mediators,and oxidative stress in-dicators in patients with chronic obstructive pulmonary disease(COPD).Methods A total of 100 COPD patients admitted to the Fourth People's Hospital of Shangqiu City from February 2022 to June 2023 were selected and divided into a control group and an observation group using a random number method.The control group received conventional treatment,while the observation group received in-travenous Erigeron breviscapus and oral roflumilast tablets on the basis of the control group's treat-ment.The clinical efficacy,lung function,immune function,cognitive function,and changes in serum inflammatory mediators and oxidative stress indicators were compared between the two groups.Results After 24 weeks of treatment,the total effective rate in the observation group was significantly high-er than that in the control group(96.0％vs 76.0％,x2=8.306,P=0.004).Both groups showed a sig-nificant increase in FVC％,FEV1％,FEV1/FVC,CD4+,and CD4+/CD8+,with a decrease in CD8+.Additionally,the changes in all indicators in the observation group were more significant than those in the control group(P＜0.05).The number and duration of acute exacerbations in the observa-tion group were significantly lower than those in the control group(P＜0.05).The St.George's Re-spiratory Questionnaire(SGRQ)scores decreased,while the Montreal Cognitive Assessment(MoCA)scores increased in both groups,and the changes in scores in the observation group were more signifi-cant than those in the control group(P＜0.05).The improvement in serum inflammatory mediators and oxidative stress indicators in the observation group was better than that in the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(22.00％vs 14.00％,X2=1.084,P=0.298).Conclusion Roflumilast combined with Erigeron brevis-capus freeze-dried powder can significantly improve lung function and immune function,reduce the oc-currence of acute exacerbations,improve cognitive function,and alleviate the damage caused by in-flammatory and oxidative stress reactions in patients with COPD,with high safety.
万方数据
维普
