Effects of alanyl-glutamine combined with octreotide and ulinastatin on BISAP score,YKL-40,and in-flammatory factors in patients with severe acute pancreatitis
Objective To evaluate the effects of alanyl-glutamine combined with octreotide and ulinastatin on serum chitinase-3-like protein 1(YKL-40),Bedside Index for Severity in Acute Pancrea-titis(BISAP)score,and inflammatory factors in patients with severe acute pancreatitis.Methods A total of 64 patients with severe acute pancreatitis admitted to our hospital from September 2020 to Sep-tember 2022 were divided into an observation group and a control group using the even-odd method,with 32 patients in each group.The observation group was treated with alanyl-glutamine combined with octreotide and ulinastatin,while the control group was treated with octreotide and ulinastatin.The clinical efficacy,inflammatory factor levels,BISAP score,YKL-40 level,microcirculation,oxi-dative stress,and adverse reactions were compared between the two groups.Results(1)The clinical total effective rate in the observation group was higher than that in the control group(P＜0.05);(2)The levels of C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),and interleukin-8(IL-8)in the observation group were significantly lower than those in the control group(P＜0.05);(3)The BISAP score and YKL-40 level in the observation group after treatment were low-er than those in the control group(P＜0.05);(4)The perfusion vessel density(PVD),perfusion vessel proportion(PPV),and microvascular flow index(MFI)levels in the observation group were higher than those in the control group(P＜0.05);(5)The superoxide dismutase(SOD)level in the observation group was higher than that in the control group,while the malondialdehyde(MDA)and reactive oxygen species(ROS)levels were lower than those in the control group(P＜0.05);(6)There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion In the treatment of severe acute pancreatitis,alanyl-glutamine combined with oct-reotide and ulinastatin shows ideal efficacy and safety,promoting the improvement of microcirculation and oxidative stress indicators,and is of great significance in reducing disease damage.It is worthy of promotion.
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