Study on the relationship between Mycoplasma pneumoniae resistance and refractory Mycoplasma pneu-moniae pneumonia in children
Objective To analyze the relationship between Mycoplasma pneumoniae(MP)resist-ance and refractory Mycoplasma pneumoniae pneumonia(RMPP)in children.Methods A retrospec-tive study was conducted on 88 children with Mycoplasma pneumoniae pneumonia(MPP)treated in Kaifeng Children's Hospital from January 2020 to January 2023.The patients were divided into a resist-ant group(69 cases)and a sensitive group(19 cases)based on the detection of Mycoplasma pneumoni-ae nucleic acid in alveolar lavage fluid.The immune response and laboratory index levels of the two groups were compared,and their clinical symptoms,treatment status,and bronchoscopic characteris-tics were also compared.Results Compared with the sensitive group,there was no significant differ-ence in the levels of white blood cells,neutrophils,CD3+T lymphocytes,CD3+CD4+T lympho-cytes,CD3-CD8 T lymphocytes,C-reactive protein(CRP),lactate dehydrogenase(LDH),and crea-tine kinase isoenzyme(CK-MB)in the resistant group(P＞0.05).However,the resistant group had longer fever duration and hospital stay,higher rates of glucocorticoid use,RMPP occurrence,and mu-cus plug obstruction,with significant differences(P＜0.05).Conclusion Mycoplasma pneumoniae resistance does not significantly affect the immune response and inflammatory response of MPP chil-dren,but it can prolong the fever duration,hospital stay,and increase the incidence of RMPP,mucus plug obstruction,and glucocorticoid use.
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