Therapeutic effect analysis of ATRA+ATO+anthracycline triple combination therapy in the treatment of non-high-risk adult acute promyelocytic leukemia
Objective To investigate the therapeutic effect of all-trans retinoic acid(ATRA)+arsenic trioxide(ATO)+anthracycline triple combination therapy on adult non-high-risk acute pro-myelocytic leukemia(APL).Methods A total of 88 adult non-high-risk APL patients treated in the First Affiliated Hospital of Henan University of Science and Technology from January 2018 to January 2022 were selected and divided into an observation group and a control group using the envelope meth-od,with 44 patients in each group.The observation group was given ATRA+ATO+anthracycline triple combination therapy,while the control group was given ATRA+ATO.The therapeutic effect,coagulation function,and improvement in quality of life were observed in both groups.Results The time to achieve complete remission(CR)in the observation group was faster than that in the control group.The coagulation reaction time(R),clot formation time(K),and prothrombin time(PT)were lower in the observation group than in the control group,while the Angle,maximum amplitude(MA),and fibrinogen(FIB)were higher(P＜0.05).After treatment,the fatigue score on the EORTC QLQ-C30 scale was lower in the observation group than in the control group,while the over-all health status score was higher(P＜0.05).Conclusion ATRA+AT()+anthracycline triple combi-nation therapy has good therapeutic effects in the treatment of adult non-high-risk acute promyelocytic leukemia,and can improve coagulation function and quality of life.
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