Correlation study between menopausal hormone therapy regimens and breast cancer risk
Objective To evaluate the correlation between menopausal hormone therapy(MHT)regimens and breast cancer(BC)risk.Methods BC patients treated at Henan Second Provincial People's Hospital from March 2020 to December 2022 were selected as the observation group,while healthy individuals undergoing physical examinations served as the control group.General information and MHT regimens were compared between the two groups.Multivariate Logistic regression analysis was conducted to explore the correlation between MHT and BC risk,and a predictive model for BC devel-opment was constructed.Results(1)Multivariate Logistic regression analysis revealed that body mass index(BMI),hypertension,diabetes,BC family history,number of pregnancies,consumption of fried foods ≥3 times/week,consumption of pickled foods ≥3 times/week,smoking,and synthetic progestogens were factors influencing BC risk(P＜0.05).Among them,the number of pregnancies was a protective factor(OR＜1).(2)The BC risk prediction model constructed through ROC analysis(including the use of synthetic progestogens)had an AUC of 0.863(95％CI:0.791-0.911),indicating a high predictive performance.Conclusion Synthetic progestogens are MHT prescription drugs associ-ated with BC risk,while micronized progesterone may be a safer option.The predictive model exhibits good predictive performance for BC risk among menopausal women.
万方数据
维普
