Efficacy of Jiangzhitongluo Capsule combined with probiotics on small intestinal bacterial overgrowth in patients with fatty liver disease
Objective To investigate the efficacy of Jiangzhitongluo Capsule combined with probi-otics in treating small intestinal bacterial overgrowth(SIBO)in patients with fatty liver disease(FLD).Methods A total of 168 FLD patients treated at Zhengzhou First People's Hospital from Janu-ary 2021 to December 2023 were selected as study subjects and randomly divided into a control group and an observation group,with 84 patients in each group.The control group was treated with Jiangzhi-tongluo Capsule,while the observation group received Jiangzhitongluo Capsule combined with probiot-ics.Clinical efficacy,SIBO positivity rate,methane and hydrogen values,and liver function laboratory indicators were compared between the two groups after treatment.Results The total effective rate in the observation group was higher than that in the control group(95.24％vs.81.18％,P＜0.05),and the SIBO positivity rate was lower(16.67％vs.41.67％,P＜0.05).The methane and hydrogen values in the observation group were lower than those in the control group(P＜0.05).There were no signif-icant differences in total bilirubin(TBIL),white blood cell(WBC),and C-reactive protein(CRP)lev-els between the two groups(P＞0.05).The levels of aspartate aminotransferase(AST),alanine ami-notransferase(ALT),γ-glutamyltransferase(γ-GGT),triglyceride(TG),and total cholesterol(TC)in the observation group were lower than those in the control group(P＜0.05).Conclusion Jiangzhi-tongluo Capsule combined with probiotics can effectively improve digestive symptoms,improve liver function,and promote the negative conversion of SIBO.
万方数据
维普
