Application progress of fecal microbiota transplantation in the treatment of ulcerative colitis
Ulcerative colitis(UC)is a chronic,non-specific inflammatory bowel disease charac-terized by abdominal pain,diarrhea,and mucopurulent bloody stool.Its etiology involves multiple fac-tors such as genetics,environment,and immune disorders.In recent years,an increasing number of studies have focused on the relationship between UC and gut microbiota,with particular attention paid to fecal microbiota transplantation(FMT).FMT directly counteracts pathogenic bacteria by transplan-ting donor gut microbiota.It also repairs damaged intestinal mucosal barriers,improves the health sta-tus of intestinal epithelial cells,and provides energy support,thereby achieving the goal of treating UC.This ultimately reconstructs gut microbiota balance and restores intestinal function.This article comprehensively reviews the role and mechanism of FMT in UC treatment,focusing on the relation-ship between UC and intestinal mucosal barriers,changes in gut microbiota and UC,as well as the ef-fectiveness and safety of FMT in UC treatment.
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