摘要
目的 探讨术前外周血白蛋白(ALB)及总蛋白(TP)水平作为子宫内膜癌(EC)患者生存及预后评估指标的可行性.方法 收集2015年1月-2020年12月于华北理工大学附属医院行初始全面分期手术的89例EC患者的临床病理资料进行回顾性分析,通过门诊或电话随访至2024年6月,统计患者无病生存期(DFS)及总生存期(OS),采用Cox回归分析评估术前ALB与TP水平对于EC患者预后的影响.结果 89例EC患者中位随访时间44个月(27～58个月),其中15例复发,4例死亡;中位DFS为44个月(15～58个月).低ALB、低TP、术后病理分期为Ⅲ-Ⅳ期与低分化是影响EC患者复发的危险因素,且术前低ALB水平、FIGO分期为Ⅲ期和Ⅳ期均为独立危险因素,HR值分别为0.74、11.99、36.05,95％CI 分别为 0.60～0.90、2.49～57.82 和 4.74～274.08.低 ALB、低 TP 和 FIGOⅢ-Ⅳ期均是导致EC患者死亡的危险因素.结论 术前外周血ALB和TP的水平可作为评估EC患者复发及预后的指标.
Abstract
Objective To explore the feasibility of preoperative peripheral serum albumin(ALB)and total protein(TP)levels as indicators for assessing survival and prognosis in patients with endom-etrial cancer(EC).Methods We retrospectively analyzed the clinicopathological data of 89 EC patients who underwent initial comprehensive staging surgery at The Affiliated Hospital of North China Uni-versity of Science and Technology between January 2015 and December 2020.Patients were followed up via outpatient visits or telephone until June 2024 to collect their disease-free survival(DFS)and o-verall survival(OS).Cox regression analysis was used to assess the impact of preoperative ALB and TP levels on the prognosis of EC patients.Results The median follow-up duration for the 89 EC pa-tients was 44 months(range:27-58 months),with 15 recurrences and 4 deaths observed.The median DFS was 44 months(range:15-58 months).Low ALB,low TP,postoperative pathological stage Ⅲ-Ⅳ,and poorly differentiated EC were identified as risk factors for recurrence in EC patients.Preopera-tive low ALB levels,stage Ⅲ,and stage Ⅳ were independent risk factors with hazard ratios(HRs)of 0.74,11.99,and 36.05,respectively,and 95％confidence intervals(CIs)of 0.60-0.90,2.49-57.82,and 4.74-274.08,respectively.Low ALB,low TP,and stages Ⅲ-Ⅳ were all risk factors for death in EC patients.Conclusion Preoperative peripheral serum ALB and TP levels can serve as indicators for assessing recurrence and prognosis in EC patients.
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