Evaluation of the prognostic value of preoperative peripheral serum albumin and total protein levels in pa-tients with endometrial cancer
Objective To explore the feasibility of preoperative peripheral serum albumin(ALB)and total protein(TP)levels as indicators for assessing survival and prognosis in patients with endom-etrial cancer(EC).Methods We retrospectively analyzed the clinicopathological data of 89 EC patients who underwent initial comprehensive staging surgery at The Affiliated Hospital of North China Uni-versity of Science and Technology between January 2015 and December 2020.Patients were followed up via outpatient visits or telephone until June 2024 to collect their disease-free survival(DFS)and o-verall survival(OS).Cox regression analysis was used to assess the impact of preoperative ALB and TP levels on the prognosis of EC patients.Results The median follow-up duration for the 89 EC pa-tients was 44 months(range:27-58 months),with 15 recurrences and 4 deaths observed.The median DFS was 44 months(range:15-58 months).Low ALB,low TP,postoperative pathological stage Ⅲ-Ⅳ,and poorly differentiated EC were identified as risk factors for recurrence in EC patients.Preopera-tive low ALB levels,stage Ⅲ,and stage Ⅳ were independent risk factors with hazard ratios(HRs)of 0.74,11.99,and 36.05,respectively,and 95％confidence intervals(CIs)of 0.60-0.90,2.49-57.82,and 4.74-274.08,respectively.Low ALB,low TP,and stages Ⅲ-Ⅳ were all risk factors for death in EC patients.Conclusion Preoperative peripheral serum ALB and TP levels can serve as indicators for assessing recurrence and prognosis in EC patients.
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维普
