Objective To analyze of the levels of 25-hydroxyvitamin D(25OHD)and parathyroid hormone(PTH)and calcitonin(CT)and analyze their clinical significance in patients with type 2 dia-betes mellitus(T2DM)peripheral neuropathy(DPN)of different severity.Methods According to the diagnostic criteria of DPN and the Toronto Clinical Scoring System(TCSS),the 281 T2DM patients were divided into four groups:no DPN,mild DPN,moderate DPN and severe DPN.Clinical data were collected,Their serum concentrations of 25OHD and PTH and CT and calcium(Ca)and phosphorus(P)and fasting plasma glucose(FPG)and 2-h postprandial glucose(2hPBG)and fasting insulin(FINS)and fasting C-peptide(FC-P)and blood lipids were measured.Multivariate analysis of factors affecting the severity of DPN using multiple ordered logistic regression.Results The more severe DPN,the longer the course of T2DM,the difference was statistically significant between the four groups(P＜0.01);the levels of 25OHD,Ca and FINS decreased with the aggravation of DPN,the levels of PTH and 2hPBG increased with the aggravation of DPN,the difference was statistically sig-nificant between groups(P＜0.05);multiple logistic ordinal regression analysis showed that the lev-els of 25OHD,Ca and FINS,were independent protective factors for the severity of DPN;while the duration of the disease,PTH and 2hPBG levels(P＜0.05)were independent risk factors for the se-verity of DPN.Conclusion The levels of 25OHD and PTH were associated with the severity of DPN and could be used as monitoring indicators for the severity of DPN.
关键词
2型糖尿病/糖尿病周围神经病变/25羟基维生素D/甲状旁腺激素/降钙素
Key words
Type 2 diabetes/Diabetes peripheral neuropathy/25-hydroxyvitamin D/Parathy-roid hormone/Calcitonin
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