Application and research progress of aptamers in the diagnosis and treatment of cardiovascular diseases
Cardiovascular diseases(CVDs)are one of the leading causes of death worldwide[1],posing a serious threat to human health.Aptamers,characterized by high specificity and affinity,can efficiently detect a variety of biomarkers,providing diagnostic results with high sensitivity and speci-ficity.In the diagnosis and treatment of CVDs,aptamers exhibit high sensitivity and specificity in de-tecting biomarkers such as troponin and B-type natriuretic peptide.Meanwhile,as targeted inhibitors,aptamers exert therapeutic effects by precisely targeting CVD-related molecules such as coagulation factors,platelet proteins,osteopontin,and proprotein convertase subtilisin/kexin type 9(PCSK9).With advancements in molecular biology technology,the screening,synthesis,and modification tech-niques of aptamers continue to be optimized,further promoting their clinical applications.
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维普
