Synthesis of Polycyclic Fused 1,5-benzoxazepine Compounds by Three-component Tandem Reaction
Using o-aminophenol,β-cyclic diketones and aromatic aldehydes as raw materials,anhydrous ethanol as solvent,and p-toluenesulfonic acid as catalyst,five new types of polycyclic 1,5-benzoxazepines were synthesized by one-pot three-component tandem reaction.This tandem reaction achieved the synthesis of seven-membered rings containing both oxygen and nitrogen heteroatoms,along with four new chemical bonds(C—O,C—N,C=C and C—C)in a reaction system.Additionally,two possible reaction mechanisms were proposed.This method has advantages including simple and mild reaction conditions,environmental friendliness,and high yields,which provides a novel reference for the synthesis of polycyclic 1,5-benzoxaz-epine compounds.
1,5-benzoxazepinethree-component tandem reactionone-pot synthesisreaction mecha-nism
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