Effects of Exercise Preintervention on Learning and Memory and Synaptic Proteins Ex-pression in Hippocampus CA1 of the Cerebral Ischemia Reperfusion Rats
Objetive The aim of the present study was to explore the possible mechanism of 4 weeks treadmill exercise preintervention in improving cognitive function of cerebral ischemia reperfusion(CI/R)rats by measuring the cerebral infarction volume,hippocampus inflammatory biomarkers levels and the synaptic proteins expression in hippocampus CA1.Methods 40 SD male rats were modeled for CI/R and the CI/R exercise group rats were subjected to 4 weeks of incremental load treadmill exercise before modeling.After 72 h of CI/R,the learning and memory ability of rats were evaluated,the cerebral infarction volume％,the level of TNF-α,IL-6 in hip-pocampus and the expression of SYN and PSD-95 in hippocampal CA1 region were measured.Results 1)Compared with the sham operation group,the escape latency significantly increased and the number of crossing the platform significantly decreased in the morris water mazet test;cerebral infarction volume％and the level of IL-6 and TNF-α in hippocampus significantly increased,while the MOD of SYN and PSD-95 in hippocampus CA1 significantly decreased.2)The 4-week treadmill exercise preintervention can signifi-cantly improve the learning and memory ability of CI/R rats,the cerebral infarction volume％and the TNF-α level in hippocampus significantly decreased;the MOD of SYN and PSD-95 had a significant up-regulation in hippocampus CA1 region in CI/R exercise group rats when compared with the CI/R model group.Conclusion Treadmill exercise preintervention might prevent memory deficits after CI/R through reducing hippocampal neuroinflammatory response,reducing cerebral infarction volume and increasing the synaptic associated protein expression in hippocampal CA1,which is considered to be an effective strategy to prevent ischemic injury.
exercise preinterventioncerebral ischemia reperfusionlearning and memoryhippocampal inflammatory cytokinessynaptophysin expression
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