Correlation Analysis Between Imaging Features Clinicopathological Characteristics and Molecular Subtypes of Non-Mass Ductal Carcinoma In Situ(DCIS)
Objective:To investigate the relationship between the imaging features and the clinicopatho-logical characteristics of non-mass ductal carcinoma in situ(DCIS)and to analyze their correlation with mo-lecular subtypes.Methods:This study selected 100 patients with non-mass DCIS who underwent surgical treat-ment at our hospital from June 2020 to June 2021.The patients were classified into four types(Type Ⅰ:31 ca-ses,Type Ⅱ:15 cases,Type Ⅲ:43 cases,and Type Ⅳ:11 cases)based on ultrasound findings.Immunohisto-chemistry was used to evaluate the positive expression of estrogen receptor(ER),progesterone receptor(PR),human epidermal growth factor receptor 2(HER2),and Ki-67.Patients were categorized into Luminal A and Luminal B molecular subtypes according to the St.Gallen standard.Results:Type Ⅰ exhibited thickened and tortuous ducts with low echogenicity within the lumen.Type Ⅱ displayed patchy hypoechoic areas with in-distinct boundaries in the breast.Type Ⅱ showed lamellar hypoechoic areas with unevenly distributed punctate strong echoes in the breast.Type Ⅳ presented disordered glandular structures with distorted architecture.There were no statistically significant differences in age,tumor diameter,menstrual status,lesion location,and clinical symptoms among patients with Type Ⅰ,Type Ⅱ,Type Ⅲ,and Type Ⅳ non-mass DCIS(P>0.05).However,as the ultrasound classification level increased,nuclear grade also increased(P<0.05).There were no signifi-cant differences in the positive expression of ER,PR,Ki-67 levels among Type Ⅰ,Type Ⅱ,Type Ⅲ and TypeⅣ non-mass DCIS patients(P>0.05).But,there was a significant difference in HER2 positive expression be-tween Type Ⅰ and Type Ⅱ,with Types Ⅲ and Ⅳ showing a higher HER2 positive expression(P<0.05).There was no significant difference in HER2 positive expression between type Ⅰ and type Ⅱ patients(P>0.05).Compared to type Ⅰ,type Ⅲ and type Ⅳ showed higher HER2 positive expression(P<0.05).Type Ⅲ had higher HER2 positive expression compared to type Ⅱ,but the difference with type Ⅳ was not statistically significant(P>0.05).The distribution of Luminal A and Luminal B subtypes increased in type Ⅲ compared to type Ⅰ(P<0.05),and the distribution of Luminal B subtype increased in type Ⅳ compared to type Ⅰ(P<0.05),while the difference in Luminal A subtype was not statistically significant(P>0.05).Conclusion:Pa-tients with non-mass DCIS mainly exhibited calcification on ultrasound.Patients with structural disorders had higher nuclear grades and more HER2 positive expression.These factors were correlated with a decrease in Lu-minal A subtype and an increase in Luminal B subtype.
Non-mass ductal carcinoma in situUltrasoundClassificationClinicopathology
国家科技期刊平台
NSTL
万方数据
维普
