首页|连续性血液净化和间歇性血液透析对老年急性肾功能衰竭患者血清RBP4 Tf β2-MG水平的影响

连续性血液净化和间歇性血液透析对老年急性肾功能衰竭患者血清RBP4 Tf β2-MG水平的影响

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
目的:探讨连续性血液净化(CBP)和间歇性血液透析(IHD)对老年急性肾功能衰竭(ARF)患者血清视黄醇结合蛋白4(RBP4)、转铁蛋白(Tf)、β2 微球蛋白(β2-MG)水平的影响。方法:纳入2021 年1 月至2023 年1 月在我院收治的114 例ARF患者为本次研究的研究对象，采取随机数字表对入组ARF患者进行简单随机分组，各57 例(观察组、对照组)。对照组予以IHD，观察组予以CBP，两组患者透析周期均为2 周。比较两组患者临床疗效，透析前、透析 2 周后血清检测水平[RBP4、Tf、β2-MG、Scr和BUN]与电解质指标(K+、Cl-、Na+)，记录两组患者并发症发生情况。结果:透析结束后，观察组与对照组ARF患者总有效率分别为94。74%(54/57)、78。95%(45/57)，差异有统计学意义(P<0。05)。透析 2 周后两组患者血清 RBP4、Tf、β2-MG、Scr、BUN 水平较之透析前明显降低，且观察组血清RBP4、Tf、β2-MG、Scr、BUN水平下降幅度均大于对照组(P<0。05)。透析 2 周后两组患者血清 K+、Cl-和Na+水平较之透析前明显升高，且观察组K+、Cl-和Na+水平升高幅度均大于对照组(P<0。05)。两组ARF患者透析期间并发症发生率(5。26%、7。02%)比较差异不显著(P>0。05)。结论:老年ARF患者应用CBP 透析效果较好，可以较大程度清除血液中的大小分子毒素，并维持电解质的稳定。
Effects of Continuous Blood Purification and Intermittent Hemodialysis on Serum RBP4 Tf and β2-MG Levels in Elderly Patients with Acute Renal Failure
Objective:To explore the effects of continuous blood purification(CBP)and intermittent hemodialysis(IHD)on levels of serum retinol-binding protein 4(RBP4),transferrin(Tf)and β2-micro-globulin(β2-MG)in elderly patients with acute renal failure(ARF).Methods:A total of 114 ARF patients admitted to our hospital from January 2021 to January 2023 were included in this study.The patients were ran-domly divided into two groups using a random number table,with 57 cases in each group(observation group and control group).The control group received IHD,and the observation group received CBP,with a dialysis period of 2 weeks for both groups.Clinical efficacy,serum levels[RBP4,Tf,β2-MG,Serum Creatinine(Scr),and Blood Urea Nitrogen(BUN)]before and 2 weeks after dialysis,as well as electrolyte indicators(K+,Cl-,Na+),were compared between the two groups.Complications during the treatment were recorded.Results:After dialysis,the total effective rates in the observation group and control group were 94.74%(54/57)and 78.95%(45/57),respectively,with a statistically significant difference(P<0.05).After 2 weeks of dialysis,the serum levels of RBP4,Tf,β2-MG,Scr,and BUN in both groups decreased significantly com-pared to before dialysis,and the reduction in the observation group was greater than that in the control group(P<0.05).After 2 weeks of dialysis,the serum levels of K+,Cl-,and Na+ in both groups increased signifi-cantly compared to before dialysis,and the increase in the observation group was greater than that in the con-trol group(P<0.05).The incidence of complications during dialysis in both groups(5.26%,7.02%)showed no significant difference(P>0.05).Conclusion:CBP is more effective in elderly ARF patients,ef-fectively removing small and large molecular toxins from the blood and maintaining electrolyte stability.

Acute renal failureContinuous blood purificationIntermittent hemodialysisReti-nol-binding protein 4Transferrinβ2-microglobulin

何丽、张凡、程彩娟、曹路路、唐琪、李奕

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西部战区总医院肾脏病科血液净化中心,四川 成都 610000

急性肾功能衰竭 连续性血液净化 间歇性血液透析 视黄醇结合蛋白4 转铁蛋白 β2微球蛋白

四川省干部保健科研项目

川干研2021-1301

2024

10.3969/j.issn.1006-6233.2024.01.013

河北医学
河北省医学会

河北医学

CSTPCD
影响因子：1.915
ISSN：1006-6233
年,卷(期)：2024.30(1)
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