血清FT3/FT4 IGFBP7与NT-proBNP预测AHF患者不良预后的价值
The Value of Serum FT3/FT4 IGFBP7 and NT proBNP in Predicting Poor Prognosis in AHF Patients
雷荣浩 1肖宝珠 1潘婉 1雷杰1
作者信息
- 1. 湖北省武汉市第一医院,湖北 武汉 430000
- 折叠
摘要
目的:探究游离三碘甲状腺原氨酸/甲状腺素比值(FT3/FT4)、胰岛素样生长因子结合蛋白7(IGFBP7)与N-端脑利钠钛(NT-ProBNP)预测急性心力衰竭(AHF)患者不良预后的价值.方法:选取2020 年2 月至2022 年2 月在我院接受诊治的AHF患者125 例,对患者进行6 个月随访调查,根据随访期内患者是否发生死亡、再发心力衰竭不良情况将患者分组:预后良好组(n=44)和预后不良组(n =81),收集两组一般资料,并对两组入院时的 FT3/FT4、IGFBP7 与 NT-proBNP 水平进行分析,探究其对AHF患者不良预后的预测价值.结果:入院时,预后不良组患者的 FT3/FT4 值低于预后良好组,IG-FBP7 与NT-proBNP 水平高于预后良好组(P<0.05).单因素分析结果可知年龄、服用β受体阻滞剂及利尿剂对患者的预后存在影响(P<0.05).以患者预后情况为因变量(预后良好=0,预后不良=1),对上述结果中组间存在差异的指标进行多因素 logistic 回归分析,可知 FT3/FT4 低水平、IGFBP7 和 NT-proBNP 高水平可能会对患者的预后不良产生影响(P<0.05).采用 ROC 曲线探究 FT3/FT4、IGFBP7与NT-proBNP 水平对患者预后不良的预测价值,其 AUC 值分别为 0.899、0.913、0.878,最佳截断值分别为69.88、336.93、0.235(P<0.05).结论:血清FT3/FT4、IGFBP7 及NT-proBNP 对AHF患者不良预后具有一定预测价值,可应用于临床.
Abstract
Objective:To explore the value of the free triiodothyronine/thyroxine ratio(FT3/FT4),in-sulin-like growth factor-binding protein7(IGFBP7),and N-terminal pro-brain natriuretic peptide(NT-proBNP)in predicting adverse outcomes of patients with acute heart failure(AHF).Methods:A total of 125 AHF patients treated at our hospital from February 2020 to February 2022 were selected.A 6-month follow-up survey was conducted,and patients were categorized into two groups based on whether adverse events such as death or recurrent heart failure occurred during the follow-up:a good prognosis group(n=44)and a poor prognosis group(n=81).General information was collected for both groups,and the FT3/FT4,IGFBP7,and NT-proBNP levels at admission were analyzed to explore their predictive value for adverse outcomes in AHF patients.Results:At admission,the FT3/FT4 levels in the poor prognosis group were lower than those in the good prognosis group,while IGFBP7 and NT-proBNP levels were higher(P<0.05).Univariate analy-sis revealed that age,use of β-blockers,and diuretics had an impact on patient prognosis(P<0.05).Multi-variate logistic regression analysis using patient prognosis as the dependent variable(good prognosis=0,poor prognosis=1)showed that low levels of FT3/FT4 and high levels of IGFBP7 and NT-proBNP may affect ad-verse outcomes in patients(P<0.05).ROC curve analysis explored the predictive value of FT3/FT4,IG-FBP7,and NT-proBNP levels for adverse outcomes,with AUC values of 0.899,0.913,and 0.878,and op-timal cutoff values of 69.88,336.93,and 0.235,respectively(P<0.05).Conclusion:Serum FT3/FT4,IGFBP7,and NT-proBNP have a certain predictive value for adverse outcomes in AHF patients and can be applied in clinical practice.
关键词
游离三碘甲状腺原氨酸/游离甲状腺素/胰岛素样生长因子结合蛋白7/N-端脑利钠钛/急性心力衰竭/不良预后Key words
Free triiodothyronine/Free thyroxine/Insulin like growth factor binding protein7/N-terminal brain natriuretic titanium/Acute heart failure/Adverse prognosis引用本文复制引用
基金项目
湖北省卫生健康委科研项目(WJ2019M032)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据