The Value of Serum FT3/FT4 IGFBP7 and NT proBNP in Predicting Poor Prognosis in AHF Patients
Objective:To explore the value of the free triiodothyronine/thyroxine ratio(FT3/FT4),in-sulin-like growth factor-binding protein7(IGFBP7),and N-terminal pro-brain natriuretic peptide(NT-proBNP)in predicting adverse outcomes of patients with acute heart failure(AHF).Methods:A total of 125 AHF patients treated at our hospital from February 2020 to February 2022 were selected.A 6-month follow-up survey was conducted,and patients were categorized into two groups based on whether adverse events such as death or recurrent heart failure occurred during the follow-up:a good prognosis group(n=44)and a poor prognosis group(n=81).General information was collected for both groups,and the FT3/FT4,IGFBP7,and NT-proBNP levels at admission were analyzed to explore their predictive value for adverse outcomes in AHF patients.Results:At admission,the FT3/FT4 levels in the poor prognosis group were lower than those in the good prognosis group,while IGFBP7 and NT-proBNP levels were higher(P<0.05).Univariate analy-sis revealed that age,use of β-blockers,and diuretics had an impact on patient prognosis(P<0.05).Multi-variate logistic regression analysis using patient prognosis as the dependent variable(good prognosis=0,poor prognosis=1)showed that low levels of FT3/FT4 and high levels of IGFBP7 and NT-proBNP may affect ad-verse outcomes in patients(P<0.05).ROC curve analysis explored the predictive value of FT3/FT4,IG-FBP7,and NT-proBNP levels for adverse outcomes,with AUC values of 0.899,0.913,and 0.878,and op-timal cutoff values of 69.88,336.93,and 0.235,respectively(P<0.05).Conclusion:Serum FT3/FT4,IGFBP7,and NT-proBNP have a certain predictive value for adverse outcomes in AHF patients and can be applied in clinical practice.
国家科技期刊平台
NSTL
万方数据
维普
