首页|血清PTX3 SFRP4联合尿NGAL对糖尿病肾病的诊断价值

血清PTX3 SFRP4联合尿NGAL对糖尿病肾病的诊断价值

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
  • 维普
目的:探讨联合检测尿中性粒细胞明胶酶相关脂质运载蛋白(NGAL)及血清正五聚蛋白3(PTX3)和分泌型卷曲相关蛋白 4(SFRP4)对临床上糖尿病肾病(DN)的诊断意义。方法:选取我院2020 年12 月至2023 年6 月就诊的DN患者86 例，作为DN组，根据尿微量白蛋白排泄率(UAER)分为早期组(24 例，UAER≤20 μg/min)、中期组(30 例，20 μg/min<UAER<200 μg/min)、晚期组(32 例，UAER≥200 μg/min)，根据病情严重程度分为轻度DN组(40 例)和中重度DN组(46 例)，另选取40 例单纯2 型糖尿病患者为对照组。比较 DN 组与对照组、不同病情程度组以及早中晚期组血清 PTX3、SFRP4 和尿液NGAL水平。分析三者及其联合检测在诊断DN中的临床价值。结果:DN组血清PTX3、SFRP4 和尿液中NGAL的水平均高于对照组(P<0。05);与轻度DN组相比中重度DN组患者三个指标的水平也明显升高(P<0。05);中、晚期组DN患者三个指标的水平较早期组升高(P<0。05)。ROC 曲线分析显示，三者联合诊断DN的曲线下面积(AUC)为 0。985，且联合诊断 AUC 大于单一指标诊断(Z 三者联合-PTX3=2。670、Z 三者联合-SFRP4 = 3。976、Z 三者联合-NGAL = 2。510，P = 0。008、0。000、0。012)，敏感度为 94。20%，特异性为 96。00%。结论:血清 PTX3、SFRP4 和尿液 NGAL 联合检测在诊断DN以及评估DN患者严重程度具有更高的可靠性。
Diagnostic Value of Combined Serum PTX3 SFRP4 and Urinary NGAL in Diabetic Nephropathy
Objective:To explore the diagnostic significance of combined detection of neutrophil gelati-nase-associated lipocalin(NGAL)in urine,serum pentraxin 3(PTX3),and secreted frizzled-related pro-tein 4(SFRP4)in clinical diabetic nephropathy(DN).Methods:A total of 86 DN patients treated at our hospital from December 2020 to June 2023 were selected as the DN group.According to urinary albumin ex-cretion rate(UAER),they were divided into the early group(24 cases,UAER≤20 μg/min),the middle group(30 cases,20 μg/min<UAER<200 μg/min),and the late group(32 cases,UAER≥200 μg/min).Based on the severity of the disease,they were further divided into mild DN group(40 cases)and moderate to severe DN group(46 cases).Additionally,40 patients with type 2 diabetes without nephropathy were selected as the control group.Serum PTX3,SFRP4,and urinary NGAL levels were compared between the DN group and the control group,among different severity groups,and between early,middle,and late-stage groups.The clinical value of the three markers and their combined detection in diagnosing DN was ana-lyzed.Results:Levels of serum PTX3,SFRP4,and urinary NGAL in the DN group were higher than those in the control group(P<0.05).Patients in the moderate to severe DN group showed significantly elevated lev-els of all three markers compared to the mild DN group(P<0.05).The levels of the three markers in the middle and late-stage DN groups were higher than those in the early-stage group(P<0.05).ROC curve a-nalysis showed that the area under the curve(AUC)for the combined diagnosis of DN by the three markers was 0.985,and the AUC for the combined diagnosis was higher than that for individual markers(Z combined-PTX3=2.670,Z combined-SFRP4=3.976,Z combined-NGAL=2.510,P =0.008,0.000,0.012).The sensitivity was 94.20%,and the specificity was 96.00%.Conclusion:Combined detection of serum PTX3,SFRP4,and urinary NGAL has higher reliability in diagnosing DN and assessing the severity of DN pa-tients.

Diabetic nephropathyPentraxin 3Secreted frizzled-related protein 4Neutrophil gelatinase-associated lipocalinDiagnostic value

王文怡、余静恬、王洁莲

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武汉科技大学附属天佑医院,湖北 武汉 430064

糖尿病肾病 正五聚蛋白3 分泌型卷曲相关蛋白4 中性粒细胞明胶酶相关脂质运载蛋白 诊断价值

职业危害识别与控制湖北省重点实验室开放基金

OHIC2020Y05

2024

10.3969/j.issn.1006-6233.2024.01.017

河北医学
河北省医学会

河北医学

CSTPCD
影响因子：1.915
ISSN：1006-6233
年,卷(期)：2024.30(1)
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