Analysis of Peripheral Blood Immune Indices in Patients with Bronchiectasis Complicated by NTM Infection
Objective:To analyze the level of peripheral blood immune spectrum in patients with bron-chiectasis complicated with nontuberculous Mycobacterium(NTM).Methods:Ninety-six patients with bron-chiectasis admitted to our hospital from May 2021 to May 2023 were selected.The patients were divided into an infection group(33 cases)and a non-infection group(63 cases)based on whether NTM infection was present.In the infection group,patients were further categorized based on the number of lung lobes affected by bronchiectasis:1～2 lobes group(11 cases),3～4 lobes group(12 cases),and 5～6 lobes group(10 ca-ses).Peripheral blood levels of immunoglobulins,T lymphocyte subsets,high-sensitivity C-reactive protein(hs-CRP),cystatin C(CysC),and homocysteine(Hcy)were compared between the groups.Results:There was no significant difference in the levels of peripheral blood immunoglobulins between the two groups(P>0.05).The peripheral blood CD3+ and CD4+ levels were lower,and CD8+ levels were higher in the in-fection group compared to the non-infection group(P<0.05).There was no significant difference in peripher-al blood Hcy levels between the two groups(P>0.05).However,hs-CRP and CysC levels were higher in the infection group than in the non-infection group(P<0.05).When comparing different groups based on the number of affected lung lobes,there was no significant difference in peripheral blood IgA,IgM,IgG,CD8+levels(P>0.05).However,the CD3+ and CD4+ levels showed a decreasing trend from the 1～2 lobes group to the 5～6 lobes group(P<0.05).There was no significant difference in peripheral blood hs-CRP,CysC,and Hcy levels among the three groups(P>0.05).Conclusion:In patients with bronchiectasis complicated by NTM infection,peripheral blood CD3+ and CD4+ levels are decreased,CD8+,hs-CRP,and CysC levels are increased.Furthermore,CD3+ and CD4+ levels are correlated with the number of affected lung lobes.
BronchiectasisNon-tuberculous mycobacteriumImmunoglobulinT lymphocyte subsetsHypersensitive C-reactive proteinCystatin C
国家科技期刊平台
NSTL
万方数据
维普
