支气管扩张合并NTM病患者外周血免疫指标谱水平分析
Analysis of Peripheral Blood Immune Indices in Patients with Bronchiectasis Complicated by NTM Infection
梅益枝 1姚超 1张毕玲1
作者信息
- 1. 安徽省胸科医院结核六科,安徽 合肥 230022
- 折叠
摘要
目的:分析支气管扩张合并非结核分枝杆菌(NTM)病患者外周血免疫指标谱水平.方法:选取2021 年5 月至2023 年5 月我院收治的96 例支气管扩张患者,根据患者是否合并NTM感染分为感染组(33 例)和未感染组(63 例),感染组依据支气管扩张受累肺叶数分为1～2 肺叶组(11 例)、3～4 肺叶组(12 例)、5～6 肺叶组(10 例).比较各组患者外周血免疫球蛋白、T 淋巴细胞亚群、超敏 C-反应蛋白(hs-CRP)、胱抑素C(CysC)、同型半胱氨酸(Hcy)水平.结果:两组外周血免疫球蛋白水平比较,差异无统计学意义(P>0.05),感染组外周血CD3+、CD4+低于未感染组(P<0.05),感染组CD8+高于未感染组(P<0.05);两组外周血Hcy比较,差异无统计学意义(P>0.05),感染组hs-CRP、CysC 水平高于未感染组(P<0.05);三组不同受累肺叶数目患者外周血IgA、IgM、IgG、CD8+比较,差异无统计学意义(P>0.05),三组不同受累肺叶数目患者CD3+、CD4+比较,1～2 肺叶组>3～4 肺叶组>5～6 肺叶组(P<0.05);三组外周血hs-CRP、CysC及Hcy水平对比,差异无统计学意义(P>0.05).结论:支气管扩张合并NTM病患者外周血CD3+、CD4+降低,CD8+、hs-CRP、CysC升高,且CD3+、CD4+水平与受累肺叶数相关.
Abstract
Objective:To analyze the level of peripheral blood immune spectrum in patients with bron-chiectasis complicated with nontuberculous Mycobacterium(NTM).Methods:Ninety-six patients with bron-chiectasis admitted to our hospital from May 2021 to May 2023 were selected.The patients were divided into an infection group(33 cases)and a non-infection group(63 cases)based on whether NTM infection was present.In the infection group,patients were further categorized based on the number of lung lobes affected by bronchiectasis:1～2 lobes group(11 cases),3～4 lobes group(12 cases),and 5～6 lobes group(10 ca-ses).Peripheral blood levels of immunoglobulins,T lymphocyte subsets,high-sensitivity C-reactive protein(hs-CRP),cystatin C(CysC),and homocysteine(Hcy)were compared between the groups.Results:There was no significant difference in the levels of peripheral blood immunoglobulins between the two groups(P>0.05).The peripheral blood CD3+ and CD4+ levels were lower,and CD8+ levels were higher in the in-fection group compared to the non-infection group(P<0.05).There was no significant difference in peripher-al blood Hcy levels between the two groups(P>0.05).However,hs-CRP and CysC levels were higher in the infection group than in the non-infection group(P<0.05).When comparing different groups based on the number of affected lung lobes,there was no significant difference in peripheral blood IgA,IgM,IgG,CD8+levels(P>0.05).However,the CD3+ and CD4+ levels showed a decreasing trend from the 1～2 lobes group to the 5～6 lobes group(P<0.05).There was no significant difference in peripheral blood hs-CRP,CysC,and Hcy levels among the three groups(P>0.05).Conclusion:In patients with bronchiectasis complicated by NTM infection,peripheral blood CD3+ and CD4+ levels are decreased,CD8+,hs-CRP,and CysC levels are increased.Furthermore,CD3+ and CD4+ levels are correlated with the number of affected lung lobes.
关键词
支气管扩张/非结核分枝杆菌/免疫球蛋白/T淋巴细胞亚群/超敏C-反应蛋白/胱抑素CKey words
Bronchiectasis/Non-tuberculous mycobacterium/Immunoglobulin/T lymphocyte subsets/Hypersensitive C-reactive protein/Cystatin C引用本文复制引用
基金项目
安徽省自然科学基金(2208085MH193)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据