Value of Combined Ultrasonic NT and LC with Maternal Blood Molecular Markers in Assessing Pregnancy Outcomes in High-Risk Pregnant Women
Objective:To explore the value of combined measurement of nuchal translucency(NT),cervical length(LC),free beta-human chorionic gonadotropin(B-HCG),pregnancy-associated plasma pro-tein-A(PAPPA),and D-dimer(D-D)in assessing pregnancy outcomes in high-risk pregnant women.Methods:A retrospective study included 80 high-risk pregnant women who visited our hospital from January 2019 to January 2022.Participants were categorized into groups with adverse pregnancy outcomes and those without.The differences in NT,LC,arterial S/D ratio,PI,RI,serum B-HCG,PAPPA,and D-D levels were compared between the two groups.The correlation between these indicators and their predictive value for adverse pregnancy outcomes were analyzed.Results:Pregnant women with adverse pregnancy outcomes had significantly higher levels of B-HCG,PAPPA,D-D,and NT(2.28±0.62 mom,0.72±0.16 mom,351.12±82.80 mg/L,and 3.78±0.81 mm,respectively)compared to those without adverse outcomes(1.75±0.41 mom,0.57±0.15 mom,295.33±85.52 mg/L,and 3.31±0.64 mm,respectively)(P<0.01).LC was sig-nificantly lower in women with adverse outcomes(24.49±4.53 mm)compared to those without adverse out-comes(31.01±5.12 mm)(P<0.01).B-HCG,PAPPA,and D-D levels were positively correlated with NT(P<0.05),while negatively correlated with LC(P<0.05).The combined use of NT,LC,B-HCG,PAP-PA,and D-D in predicting adverse pregnancy outcomes in high-risk pregnant women had an AUC of 0.911(95%CI:0.848-0.974),significantly higher than individual indicators.The sensitivity and specificity were 79.20%and 96.30%,respectively(P<0.01).Conclusion:NT,LC,B-HCG,PAPPA,and D-D are correlated with adverse pregnancy outcomes in high-risk pregnant women,and their combined use has good predictive value for adverse pregnancy outcomes in high-risk pregnancies.
High risk pregnancyPregnancy outcomeThickness of neck transparent layerLength of cervixFree human chorionic gonadotropinPregnancy related plasma proteinD dimer
国家科技期刊平台
NSTL
万方数据
维普
