摘要
目的:探讨超声颈项透明层厚度(NT)、子宫颈长度(LC)联合游离人绒毛膜促性腺激素(B-HCG)、妊娠相关血浆蛋白(PAPPA)、D 二聚体(D-D)评估高危妊娠产妇妊娠结局的价值.方法:回顾性选取2019 年1 月至2022 年1 月在我院就诊的高危妊娠产妇80 例作为研究对象,根据是否发生不良妊娠结局分为有不良妊娠结局组和无不良妊娠结局组,比较两组 NT、LC、动脉 S/D、PI、RI 以及血清B-HCG、PAPPA、D-D的差异,以及指标间的相关性和对不良妊娠结局的预测价值.结果:有不良妊娠结局产妇的B-HCG、PAPPA、D-D和NT分别为(2.28±0.62)mom、(0.72±0.16)mom、(351.12±82.80)mg/L和(3.78±0.81)mm,明显高于无不良妊娠结局产妇(1.75±0.41)mom、(0.57±0.15)mom、(295.33±85.52)mg/L和(3.31±0.64)mm(P<0.01),而LC为(24.49±4.53)mm,明显低于无不良妊娠结局产妇(31.01±5.12)mm(P<0.01).B-HCG、PAPPA、D-D水平与NT呈正相关(P<0.05),而与LC呈负相关(P<0.05).NT、LC联合B-HCG、PAPPA、D-D预测高危妊娠产妇不良妊娠结局的ROC 曲线下面积为0.911(95CI:0.848～0.974),明显高于各指标单独预测,其灵敏性和特异性分别为 79.20%和96.30%,P<0.01.结论:NT、LC及B-HCG、PAPPA、D-D与高危妊娠产妇不良妊娠结局有相关性,在预测高危妊娠产妇不良妊娠结局中有较好的价值.
Abstract
Objective:To explore the value of combined measurement of nuchal translucency(NT),cervical length(LC),free beta-human chorionic gonadotropin(B-HCG),pregnancy-associated plasma pro-tein-A(PAPPA),and D-dimer(D-D)in assessing pregnancy outcomes in high-risk pregnant women.Methods:A retrospective study included 80 high-risk pregnant women who visited our hospital from January 2019 to January 2022.Participants were categorized into groups with adverse pregnancy outcomes and those without.The differences in NT,LC,arterial S/D ratio,PI,RI,serum B-HCG,PAPPA,and D-D levels were compared between the two groups.The correlation between these indicators and their predictive value for adverse pregnancy outcomes were analyzed.Results:Pregnant women with adverse pregnancy outcomes had significantly higher levels of B-HCG,PAPPA,D-D,and NT(2.28±0.62 mom,0.72±0.16 mom,351.12±82.80 mg/L,and 3.78±0.81 mm,respectively)compared to those without adverse outcomes(1.75±0.41 mom,0.57±0.15 mom,295.33±85.52 mg/L,and 3.31±0.64 mm,respectively)(P<0.01).LC was sig-nificantly lower in women with adverse outcomes(24.49±4.53 mm)compared to those without adverse out-comes(31.01±5.12 mm)(P<0.01).B-HCG,PAPPA,and D-D levels were positively correlated with NT(P<0.05),while negatively correlated with LC(P<0.05).The combined use of NT,LC,B-HCG,PAP-PA,and D-D in predicting adverse pregnancy outcomes in high-risk pregnant women had an AUC of 0.911(95%CI:0.848-0.974),significantly higher than individual indicators.The sensitivity and specificity were 79.20%and 96.30%,respectively(P<0.01).Conclusion:NT,LC,B-HCG,PAPPA,and D-D are correlated with adverse pregnancy outcomes in high-risk pregnant women,and their combined use has good predictive value for adverse pregnancy outcomes in high-risk pregnancies.
国家科技期刊平台
NSTL
维普
万方数据