目的:探讨多囊卵巢综合征(PCOS)不孕患者合并代谢综合征(MS)发生情况及其与促排卵结局的关系。方法:选取2020 年1 月至2023 年4 月收治的PCOS 不孕患者 225 例作为研究对象，统计MS的发生情况。根据患者是否发生MS分为MS组和非MS组，比较两组临床资料，并分析MS 与促排卵结局的关系。结果:共纳入225 例PCOS 不孕患者，31 例患者合并MS，占比为 13。78%;MS 组 BMI(≥24kg/m2)、腰围(≥88cm)、收缩压(≥130mmHg)、舒张压(≥85mmHg)、FPG(≥126mg/dL)、TG(≥150mg/dL)、FINS、HOMA-IR水平高于非MS组，HDL-C(≥59mg/dL)水平低于非 MS 组(P<0。05);MS组排卵率、临床妊娠率低于非 MS 组(χ2 =6。745;χ2 =5。292，P<0。05);采用二元 Logistic 分析，年龄(≥30 岁)、腰围(≥88cm)、MS(是)、FINS、HOMA-IR、雌二醇(E2)、睾酮(T)、抗苗勒管激素(AMH)均为影响PCOS不孕患者促排卵结局的独立危险因素(P<0。05)。结论:PCOS 不孕患者 MS 发生率较高，其促排卵结局与MS具有一定的相关性，且促排卵结局受年龄、腰围、MS、FINS、HOMA-IR、E2、T、AMH 等因素的影响。
Occurrence of Metabolic Syndrome in Infertile Patients with Polycystic Ovary Syndrome(PCOS)and Its Relationship with Ovulation Induction Outcomes
Objective:To explore the occurrence of metabolic syndrome(MS)and its relationship with ovulation induction outcomes in infertility patients with polycystic ovary syndrome(PCOS).Methods:A total of 225 infertile PCOS patients admitted from January 2020 to April 2023 were selected as the study subjects,and the occurrence of MS was recorded.Based on whether MS occurred or not,patients were divided into the MS group and the non-MS group.Clinical data were compared between the two groups,and the relationship between MS and ovulation induction outcomes was analyzed.Results:Among the 225 PCOS infertile patients,31 patients had concomitant MS,accounting for 13.78%.In the MS group,BMI(≥24 kg/m2),waist circ-umference(≥88cm),systolic blood pressure(≥130 mmHg),diastolic blood pressure(≥85 mmHg),FPG(≥126 mg/dL),TG(≥150 mg/dL),FINS,HOMA-IR levels were higher than those in the non-MS group,while HDL-C(≥59 mg/dL)level was lower than the non-MS group(P<0.05).The ovulation rate and clinical pregnancy rate in the MS group were lower than those in the non-MS group(χ2=6.745;χ2=5.292,P<0.05).Binary logistic analysis showed that age(≥30 years),waist circumference(≥88cm),MS(yes),FINS,HOMA-IR,estradiol(E2),testosterone(T),anti-Müllerian hormone(AMH)were inde-pendent risk factors affecting ovulation induction outcomes in PCOS infertile patients(P<0.05).Conclusion:The occurrence of MS is relatively high in PCOS infertile patients,and it is correlated with ovulation induction outcomes.Ovulation induction outcomes are influenced by factors such as age,waist circumference,MS,FINS,HOMA-IR,E2,T,AMH.
国家科技期刊平台
NSTL
万方数据
维普
