Correlation Analysis of Gut Microbiota Metabolites Short-Chain Fatty Acids(SCFAs)and Skeletal Muscle Mass in Healthy Children Aged 6～9
Objective:To explore the correlation between gut microbiota metabolites,specifically short-chain fatty acids(SCFAs),and skeletal muscle mass in healthy children aged 6-9.Methods:This cross-sectional study was conducted from December 2021 to January 2023.A total of 176 participants(68 girls and 108 boys)were included in the study.Skeletal muscle mass indices were measured using dual-energy X-ray absorptiometry(DXA),and participants were stratified based on bone mineral density(BMD)values.The concentration of SCFAs in feces was determined using high-performance liquid chromatography(HPLC).Spearman correlation analysis was performed to assess the relationship between fecal SCFAs and skeletal mus-cle mass.Results:Based on TBLH bone density reference values,children included in the study were classi-fied into normal BMD(Z score≥0,n = 120)and low BMD(Z score<0,n = 56)groups.Compared to the normal BMD group,the low BMD group showed significantly lower TB BMD,TBLH BMD,LS BMD,PELV BMD,TSM/TBF,ASM/AFM(P<0.05),and significantly increased TSM,ASM(P<0.05).The low BMD group had a significantly higher level of fecal butyric acid and significantly lower levels of acetic acid,propionic acid,total SCFAs compared to the normal BMD group(P<0.05).After adjusting for covariates and false discovery rate(FDR)correction,multivariate regression analysis showed a significant positive correlation between TBLH BMD,PELV BMD,and butyric acid,propionic acid,and total SCFAs(β=0.15～0.23,P<0.05).Conclusion:Fecal butyric acid,propionic acid,and total SCFAs are positively correlated with bone mineral density(BMD)in healthy children aged 6～9.
Short-chain fatty acidsChildrenBone mineral densitySkeletal health
国家科技期刊平台
NSTL
万方数据
维普
