Expression of miR-181b miR-210 and miR-126 in Pregnancy-Induced Hypertensive Disorders and Their Correlation with Inflammatory Response
Objective:To explore the expressions of serum micrornA-181b(miR-181b),miR-210 and miR-126 in hypertensive diseases in pregnancy(HDP)and its correlation with inflammation response.Methods:A total of 213 cases of singleton pregnant women with HDP treated at Chengde Maternal and Child Health Hospital from January 2018 to December 2019 were selected as the observation group.Based on the se-verity of the condition,they were divided into gestational hypertension(GH group,62 cases),mild pre-eclampsia(MP group,90 cases),and severe preeclampsia(SP group,61 cases).Additionally,78 healthy pregnant women treated during the same period in the same hospital were selected as the control group.The relative expression levels of miR-181b,miR-210,and miR-126,as well as serum interleukin-1β(IL-1β),interleukin-6(IL-6),interleukin-10(IL-10),interleukin-17(IL-17),tumor necrosis factor-α(TNF-α),monocyte chemoattractant protein-1(MCP-1),and vascular cell adhesion molecule-1(VCAM-1)levels were detected.The correlation between various indicators in HDP patients was analyzed.Results:The relative expression levels of miR-181b,miR-210,IL-1β,IL-6,IL-17,TNF-α,MCP-1,and VCAM-1 in the observation group were higher than those in the control group(P<0.05).The relative ex-pression level of miR-126 and IL-10 in the observation group were lower than those in the control group(P<0.05).In the GH group,the relative expression levels of miR-181b,miR-210,IL-1β,IL-6,IL-17,TNF-α,MCP-1,and VCAM-1 were lower than those in the MP and SP groups,and the MP group was low-er than the SP group(P<0.05).The relative expression level of miR-126 and IL-10 in the GH group were higher than those in the MP and SP groups,and the MP group was higher than the SP group(P<0.05).Pearson correlation analysis showed that the relative expression levels of miR-181b,miR-210 in HDP pa-tients were positively correlated with IL-1β,IL-6,IL-17,TNF-α,MCP-1,and VCAM-1,and negatively correlated with IL-10(P<0.05).The relative expression level of miR-126 in HDP patients was negatively correlated with IL-1β,IL-6,IL-17,TNF-α,MCP-1,and VCAM-1,and positively correlated with IL-10(P<0.05).Conclusion:miR-181b,miR-210 are highly expressed,and miR-126 is lowly expressed in HDP.All three are closely related to the inflammatory response in HDP.
Hypertensive disorders in pregnancyMicrornA-181bMicrornA-210MicrornA-126
国家科技期刊平台
NSTL
万方数据
维普
