The Impact of Bevacizumab Combined with Capecitabine Maintenance on the Prognosis of Patients with Advanced Colorectal Cancer
Objective:To explore the impact of bevacizumab combined with capecitabine maintenance on the prognosis of patients with advanced colorectal cancer.Methods:Clinical data of 101 patients with ad-vanced colorectal cancer treated in our hospital from January 2017 to January 2019 were collected.All patients received first-line chemotherapy based on 5-fluorouracil and capecitabine,combined with bevacizumab and mFOLFOX6 or XELOX regimen.Among them,42 patients received capecitabine monotherapy maintenance treatment after first-line chemotherapy(control group),and 59 patients received bevacizumab combined with capecitabine maintenance treatment(observation group).Both groups were treated until disease progression or intolerable toxic reactions.The maintenance treatment time,disease control time,Karnofsky Performance Sta-tus(KPS),Eastern Cooperative Oncology Group performance status(ZPS),serum tumor marker levels,ad-verse reactions,and long-term prognosis were compared between the two groups.Results:The maintenance treatment time and disease control time in the observation group were both longer than those in the control group(P<0.05).Both groups showed an increase in KPS and a decrease in ZPS after treatment,and the change in the observation group was greater than that in the control group(P<0.05).The serum levels of CEA,CA199,and CA724 in both groups decreased compared to before treatment,and the change in the ob-servation group was greater than that in the control group(P<0.05).There was no statistically significant difference in the occurrence of adverse reactions between the two groups(P>0.05).The overall survival rate in the observation group was higher than that in the control group(P<0.05).Conclusion:Bevacizumab com-bined with capecitabine maintenance treatment after first-line treatment for advanced colorectal cancer is safe and effective,prolonging survival time with mild adverse reactions.
国家科技期刊平台
NSTL
万方数据
维普
