Objective:To evaluate the combination of osteopontin and cystatin C in diagnosis of coronary heart disease.Methods:Serum levels of OPN and Cys-C were measured in 148 patients who underwent coro-nary angiography in our hospital.These patients were grouped according to the diseases they had and clinical data of them were collected.Results:Logistic regression analysis showed that OPN and Cys-c could inde-pendently predict CHD.ROC curve showed that the AUC of osteopontin combined with cystatin C in the diag-nosis of CHD was 0.830,the sensitivity was 76.42%,and the specificity was 81.16%.The results of com-parison of OPN and Cys-c levels between different groups showed OPN level was significantly higher in the UAP group than that in SAP group,but significantly lower than that in the AMI group.The level of Cys-c in-creased in UAP group compared with that in SAP group and the level of Cys-c decreased in AMI group com-pared with that in UAP group(P<0.05).But the changes of Cys-c in different groups were not statistically significant(P>0.05).Conclusion:Our study demonstrated OPN and Cys-c have diagnostic values for CHD,and dynamic detections of OPN and Cys-c are helpful for disease monitoring.
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