Application Value of Contrast-Enhanced Ultrasound Parameters on Evaluating Neovascularization Grading and Carotid Plaque Stability in Patients with Acute Cerebral Infarction
Objective:To explore the application value of contrast-enhanced ultrasound(CEUS)pa-rameters on evaluating the neovascularization grading and carotid plaque stability in patients with acute cere-bral infarction(ACI).Methods:A total of 115 patients with ACI admitted to our hospital from May 2020 to May 2023 were selected.All patients underwent CEUS examination,and the CEUS parameters[time to peak(Tp),mean transit time(MTT),area under the time-intensity curve(AUCt),peak intensity(PI)]were compared among patients with different neovascularization grades and carotid plaque stability,and the correla-tion between CEUS parameters and ACI neovascularization grading was analyzed by Spearman correlation anal-ysis.The application value of CEUS parameters on evaluating carotid plaque stability was analyzed by receiver operating characteristic(ROC)curve.Results:CEUS detected 11 cases of neovascularization grade 0,33 ca-ses of grade 1 and 71 cases of grade 2,accounting for 9.57%,28.70%and 61.74%respectively.The Tp and MTT in the three groups were manifested as grade 0>grade 1>grade 2(P<0.05),and the AUCt and PI were shown as grade 0<grade 1<grade 2(P<0.05).Spearman correlation analysis found that Tp and MTT were negatively correlated with neovascularization grading(P<0.05)while AUCt and PI were positively corre-lated with neovascularization grading(P<0.05).CEUS detected 85 cases of soft plaque(unstable)(73.91%)and 30 cases of stable plaque,including 14 cases of hard plaque(12.17%)and 16 cases of mixed plaque(13.91%).Tp and MTT in the three groups showed soft plaque<mixed plaque<hard plaque(P<0.05)while AUCt and PI were shown as soft plaque>mixed plaque>hard plaque(P<0.05).ROC curve anal-ysis showed that Tp,MTT,AUCt,PI and combined detection(parallel diagnosis)had predictive efficiency on ACI soft plaques(P<0.05),with AUCs of 0.778,0.724,0.830,0.817 and 0.833 respectively,and single detection of AUC had the highest efficiency,but was still lower than the combined detection.Conclu-sion:The neovascularization grading in patients with ACI is negatively correlated with Tp and MTT,and is positively correlated with AUCt and PI.The detection of Tp,MTT,AUCt and PI can guide the neovascular-ization grading of patients.In addition,the Tp and MTT of patients with carotid unstable plaque are lower than those in patients with good stability,and the AUCt and PI are higher than those in patients with good stability.CEUS parameters are effective in assessing the ACI carotid plaque stability.
万方数据
维普
