Analysis of Coagulation Function and Peripheral Blood TIM-3 TAT ACE2 Levels in Patients with Acute Pancreatitis and Secondary Organ Failure
Objective:This study aimed to investigate alterations in coagulation function among patients with acute pancreatitis(AP)and secondary organ failure(OF)and analyze variations in peripheral blood lev-els of T cell immunoglobulin and mucin domain 3(TIM-3),thrombin-antithrombin complex(TAT),and angiotensin-converting enzyme 2(ACE2).Methods:Conducted between August 2020 and August 2022,the study involved 118 patients with AP admitted for treatment.Patient severity was assessed using the Atlanta Classification and categorized into mild(n=72)and severe(n=46)groups.Coagulation function indices and peripheral blood TIM-3,TAT,ACE2 levels were compared between the groups,investigating the relationship between secondary organ failure and these parameters.Results:Patients in the severe group exhibited signifi-cantly elevated coagulation function indices(PT,INR,APTT,and FIB)and higher peripheral blood TIM-3 and TAT levels compared to the mild group,while ACE2 levels were lower(P<0.05).Similarly,the second-ary OF group showed markedly higher coagulation function indices and peripheral blood TIM-3 and TAT levels than the non-OF group,with lower ACE2 levels(P<0.05).Multifactorial analysis indicated that PT,INR,APTT,FIB,TIM-3,TAT,and ACE2 influenced the onset of secondary organ failure.The area under the ROC curve for secondary organ failure was 0.846,0.926,0.819,0.862,0.751,0.847,and 0.858 for PT,INR,APTT,FIB,TIM-3,TAT,and ACE2,respectively.Conclusion:In patients with acute pancreatitis,abnormal coagulation and elevation of TIM-3,TAT and decreased ACE 2 in peripheral blood are strongly as-sociated with disease severity,with potential predictive value for the risk of organ failure secondary to acute pancreatitis.
万方数据
维普
