Relationship between Levels of IgA,D-Dimer,and Fibrinogen Degradation Products and Disease Recurrence in Children with Henoch-Schonlein Purpura
Objective:To explore the relationship between immunoglobulin A(IgA),D-dimer(D-D),fibrinogen degradation products(FDP)levels,and disease recurrence in children with Henoch-Schon-lein Purpura(HSP).Methods:A total of 160 children with HSP admitted to our hospital from November 2022 to April 2023 were selected as the study subjects.IgA levels were measured using a fully automatic bio-chemical analyzer,and D-D and FDP levels were determined using a fully automatic blood coagulation analy-zer.After a 6-month follow-up,the patients were divided into the recurrence group(n=34)and the non-re-currence group(n=136)based on the follow-up results.The levels of IgA,D-D,and FDP were compared between the two groups.Receiver operating characteristic(ROC)curves and area under the curve(AUC)were used to analyze the predictive value of each indicator for disease recurrence.Multifactorial logistic regres-sion analysis was employed to assess the impact of various indicators on disease recurrence.Results:Children in the recurrence group had higher levels of IgA[3.305(2.565,4.402)g/L],D-D[1.470(0.477,2.742)μg/mL],and FDP[4.445(2.442,9.212)μg/mL]compared to the non-recurrence group with IgA[2.360(1.697,3.012)g/L],D-D[0.310(0.200,0.575)μg/mL],and FDP[1.920(1.140,2.890)μg/mL],and the differences were statistically significant(P<0.05).ROC curve analysis revealed that the AUC for the combined prediction of IgA,D-D,and FDP for disease recurrence in HSP children was 0.892,higher than individual indicators,with a sensitivity of 85.3%and specificity of 82.5%.Multifactorial logistic analysis showed that IgA>3.235 g/L,D-D>0.415 μg/mL,and FDP>3.260μg/mL were independent factors for HSP recurrence(P<0.05).Conclusion:IgA,D-D,and FDP levels have a certain predictive value for disease recurrence in HSP.Monitoring the levels of these three indicators is beneficial for evaluating the prog-nosis.
万方数据
维普
