Characteristics of Autonomic Nervous Function in Patients with Anxiety and Depression Analyzed by Transcranial Doppler Upright Tilt Test
Objective:To analyze the characteristics of autonomic nervous function in patients with anxi-ety and depression based on transcranial Doppler(TCD)upright tilt test.Methods:A total of 80 patients with anxiety and depression who were admitted to our hospital from March 2021 to February 2023 were selected as the case group,and another 80 healthy patients who underwent physical examination in our hospital during the same period were selected as the control group.Both groups underwent TCD,upright tilt test,and dynamic e-lectrocardiogram(DCG)examinations.The occurrence rate of incomplete W wave rebound,hemodynamics during the upright tilt test,TCD cerebral blood flow,and heart rate variability(HRV)were compared be-tween the two groups.Pearson correlation analysis was used to analyze the correlation between hemodynamics during the upright tilt test,TCD cerebral blood flow,and HRV.ROC curve analysis was performed to evaluate the predictive value of TCD combined with the upright tilt test for the occurrence of anxiety and depression.Results:Compared with the control group,the incidence of W wave callback insufficiency in the case group was significantly higher,with a statistically significant difference(11.25%VS 0.00%,χ2=5.378,P=0.020).In the case group,HR in the upright tilt position was higher than that in the control group,while DBP and SV were lower(t=6.532,7.944,6.152,P all=0.000).The absolute values of changes in DBP,HR,and SV from the supine position to the upright tilt position were higher in the case group than in the control group(t=12.015,6.644,5.635,P all=0.000).Vd,Vs,Vm in the upright tilt position were lower,and RI,PI were higher in the case group compared to the control group(t=10.488,3.927,11.256,2.298,5.918,P=0.000,0.000,0.000,0.023,0.000).The absolute values of changes in Vd,Vs,Vm,RI,and PI from the supine position to the upright tilt position were higher in the case group than in the control group(t=9.559,10.943,10.775,10.738,28.236,P all=0.000).LF,HF,PNN50,RMSSD,SDNN were lower in the case group compared to the control group(t=10.992,12.098,12.376,6.078,7.758,P all= 0.000).Pearson correlation analysis showed negative correlations between the absolute values of changes in DBP,HR,SV,Vd,Vs,Vm,RI,PI,and LF,HF,PNN50,RMSSD,SDNN from the supine position to the upright tilt position(r<0,P<0.05).ROC curve analysis revealed that the AUCs for the absolute values of changes in DBP,HR,SV,Vd,Vs,Vm,RI,PI,and the combined prediction of anxiety and depression from the supine position to the upright tilt position were 0.603,0.728,0.802,0.805,0.756,0.710,0.783,0.739,and 0.949,respectively.Conclusion:TCD combined with upright tilt test can effectively pre-dict the occurrence of anxiety and depression,and both can reflect the characteristics of autonomic nervous function in patients.
Anxiety and depressionTranscranial dopplerUpright tilt testAutonomic nervous function
万方数据
维普
