Pulmonary Infection Airway Inflammatory Injury Changes Significance of Serum SAA and CRP in Elderly Patients with COPD and Obstructive Sleep Apnea Syndrome
Objective:To explore pulmonary infection,airway inflammatory injury,changes significance of serum amyloid A(SAA)and C-reactive protein(CRP)in elderly patients with chronic obstructive pulmo-nary disease(COPD)and obstructive sleep apnea syndrome(OSAS).Methods:A total of 120 elderly pa-tients with COPD and OSAS and 120 elderly patients only with COPD in the hospital were enrolled as COPD combined OSAS group and simple COPD group between January 2021and June 2023.The detection rate of pulmonary infection and levels of serum IL-6,IL-10,IL-1β,COX-2,CRP and SAA were compared be-tween the two groups.The levels of serum indexes in patients with pulmonary infection and those without infec-tion were compared.The evaluation efficiency of serum CRP and SAA for pulmonary infection was analyzed by ROC curves.Results:The detection rate of pulmonary infection in COPD combined OSAS group was higher than that in simple COPD group(28.33%vs 17.50%,P<0.05),and levels of serum IL-6,IL-10,IL-1β,COX-2,CRP and SAA were also higher than those in simple COPD group(P<0.05).The levels of ser-um CRP and SAA in patients with pulmonary infection were significantly higher than those in patients without infection(P<0.05).ROC curves analysis showed that AUC values of serum CRP,SAA and combined detec-tion for evaluating pulmonary infection were 0.834,0.894 and 0.929,respectively(P<0.05).Conclusion:The levels of serum CRP,SAA and airway inflammatory injury indexes are abnormally increased in elderly pa-tients with COPD and OSAS.The combined detection of serum CRP and SAA has the best evaluation efficien-cy for pulmonary infection.
万方数据
维普
