Effect of Reflux Disease on the Expression Levels and Clinical Manifestations of Serum IL-10 TGF-β1 sPD-1 and sPD-L1 in Patients with Chronic Obstructive Pulmonary Disease
Objective:To analyze the influence of gastroesophageal reflux disease(GRED)on the ex-pression levels and clinical manifestations of serum interleukin-10(IL-10),transforming growth factor-β1(TGF-β1),soluble programmed death receptor-1(sPD-1)and sPD-1 ligand(sPD-L1)in patients with chronic obstructive pulmonary disease(COPD).Methods:A total of 104 COPD patients admitted to our hos-pital from January 2022 to September 2023 were divided into combined group and non-combined group ac-cording to whether the patients were complicated with reflux disease.The lung function,IL-10,TGF-β1,sPD-L1 and sPD-1 expression levels and clinical manifestations were compared between the two groups.Re-sults:Among 104 COPD patients,32 cases were complicated with GERD,accounting for 30.77%.IL-10 in the combined group was lower than that in the non-combined group,and its TGF-β1,sPD-1 and sPD-L1 were higher than those in the non-combined group,with statistical significance(P<0.05).FEV1,FEV1/FVC and FEV1%in the combined group were lower than those in the non-combined group,and the difference was statistically significant(P<0.05).The combined group had higher cough symptoms,cough effects,ex-pectoration symptoms,expectoration effects scores,mMRC scores,SGRQ scores and total scores than the non-combined group,and the difference was statistically significant(P<0.05).Conclusion:Nearly one third of COPD patients are complicated with GERD,and GERD is related to the stronger inflammatory reaction and the high expression of sPD-1 and sPD-L1,accompanied by worse lung function and more serious clinical mani-festations.
Chronic obstructive pulmonary diseaseReflux diseaseSoluble programmed death receptor
万方数据
维普
