Effects of Ticagrelor Combined with PCI on Oxidative Stress Injury Cardiac Function and Adverse Cardiovascular Events in Elderly Patients with Acute Myocardial Infarction
Objective:To observe the effects of Ticagrelor combined with percutaneous coronary inter-vention(PCI)on oxidative stress injury,cardiac function and adverse cardiovascular events in elderly patients with acute myocardial infarction.Methods:A total of 160 elderly patients with acute myocardial infarction who underwent PCI treatment in our hospital from January 2020 to June 2021 were selected as the study sub-jects.They were randomly divided into two groups using a random number table method,with a single group of 80 patients.Both groups received PCI treatment,the control group received dual antiplatelet therapy of as-pirin combined with clopidogrel,and the observation group received antiplatelet therapy of aspirin combined with tigrel.Compare the differences in cardiac function,oxidative stress injury,high sensitivity C-reactive protein(hs CRP),soluble CD40 ligand(sCD40L),N-terminal proBNP precursor(NT-proBNP),and acti-vated platelet glycosylation complex(PAC-1)between the two groups,and analyze the occurrence of major adverse cardiovascular events(MACE)between the two groups.Results:Before treatment,there was no sta-tistically significant difference in cardiac function between the two groups(P>0.05).Compared with before treatment,the left ventricular ejection fraction(LVEF),stroke volume(SV),and cardiac index(CI)of the two groups increased at 4 and 24 weeks of treatment.There was no statistically significant difference in cardiac function between the two groups(P>0.05).Before treatment,there was no statistically significant difference in the indicators of oxidative stress damage,hs CRP,NT-proBNP,sCD40L,and PAC-1 between the two groups(P>0.05).Compared with before treatment,hs CRP,NT-proBNP,malondialdehyde(MDA),sCD40L,and PAC-1 in both groups decreased at 4 and 24 weeks of treatment.The observation group was lower than the control group at 4 and 24 weeks of treatment(P<0.05),and the levels of superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)in both groups increased at 4 and 24 weeks of treatment.The observation group was higher than the control group at 4 and 24 weeks of treatment(P<0.05).The incidence of MACE in the observation group was 7.50%(6/80),lower than the control group's 18.75%(15/80)(P<0.05),and the cumulative incidence of adverse reactions was 13.75%(11/80).There was no statistically significant difference(P>0.05)compared to the control group's 11.25%(9/80).Conclusion:Tiagrelor combined with PCI in the treatment of elderly patients with acute myocardial infarction can reduce oxidative stress injury,reduce the expression levels of hs-CRP and NT-proBNP,and reduce the occurrence of MACE.
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维普
