Effects of Ticagrelor Combined with PCI on Oxidative Stress Injury Cardiac Function and Adverse Cardiovascular Events in Elderly Patients with Acute Myocardial Infarction
Effects of Ticagrelor Combined with PCI on Oxidative Stress Injury Cardiac Function and Adverse Cardiovascular Events in Elderly Patients with Acute Myocardial Infarction
Objective:To observe the effects of Ticagrelor combined with percutaneous coronary inter-vention(PCI)on oxidative stress injury,cardiac function and adverse cardiovascular events in elderly patients with acute myocardial infarction.Methods:A total of 160 elderly patients with acute myocardial infarction who underwent PCI treatment in our hospital from January 2020 to June 2021 were selected as the study sub-jects.They were randomly divided into two groups using a random number table method,with a single group of 80 patients.Both groups received PCI treatment,the control group received dual antiplatelet therapy of as-pirin combined with clopidogrel,and the observation group received antiplatelet therapy of aspirin combined with tigrel.Compare the differences in cardiac function,oxidative stress injury,high sensitivity C-reactive protein(hs CRP),soluble CD40 ligand(sCD40L),N-terminal proBNP precursor(NT-proBNP),and acti-vated platelet glycosylation complex(PAC-1)between the two groups,and analyze the occurrence of major adverse cardiovascular events(MACE)between the two groups.Results:Before treatment,there was no sta-tistically significant difference in cardiac function between the two groups(P>0.05).Compared with before treatment,the left ventricular ejection fraction(LVEF),stroke volume(SV),and cardiac index(CI)of the two groups increased at 4 and 24 weeks of treatment.There was no statistically significant difference in cardiac function between the two groups(P>0.05).Before treatment,there was no statistically significant difference in the indicators of oxidative stress damage,hs CRP,NT-proBNP,sCD40L,and PAC-1 between the two groups(P>0.05).Compared with before treatment,hs CRP,NT-proBNP,malondialdehyde(MDA),sCD40L,and PAC-1 in both groups decreased at 4 and 24 weeks of treatment.The observation group was lower than the control group at 4 and 24 weeks of treatment(P<0.05),and the levels of superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)in both groups increased at 4 and 24 weeks of treatment.The observation group was higher than the control group at 4 and 24 weeks of treatment(P<0.05).The incidence of MACE in the observation group was 7.50%(6/80),lower than the control group's 18.75%(15/80)(P<0.05),and the cumulative incidence of adverse reactions was 13.75%(11/80).There was no statistically significant difference(P>0.05)compared to the control group's 11.25%(9/80).Conclusion:Tiagrelor combined with PCI in the treatment of elderly patients with acute myocardial infarction can reduce oxidative stress injury,reduce the expression levels of hs-CRP and NT-proBNP,and reduce the occurrence of MACE.
维普
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