摘要
目的:分析无创机械通气(NIV)治疗慢性阻塞性肺疾病急性加重期(AECOPD)合并高碳酸血症的临床疗效及对血气分析、炎性因子的影响.方法:回顾性分析我院2022 年4 月至 2023 年 4 月治疗的118 例AECOPD合并高碳酸血症患者进行研究,根据治疗的差异将其分为对照组 58 例(采用氧疗与常规药物治疗)和观察组60 例(采用NIV治疗).对比两组临床疗效、血气指标[酸碱度(pH)、动脉血氧分压(PaO2)、动脉二氧化碳分压(PaCO2)]、炎性因子[白介素-6(IL-6)、白介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)]以及T淋巴细胞亚群[CD3+、CD4+、CD4+/CD8+].结果:对照组(63.79%)的总有效率低于观察组(81.67%)(P<0.05);两组治疗前的PaO2、pH、PaCO2 比较,差异无统计学意义(P>0.05).两组治疗前后PaO2、pH、PaCO2 差值比较(P>0.05);两组治疗前IL-6、IL-10、TNF-α 水平比较(P>0.05);观察组治疗前后 IL-6、IL-10、TNF-α 差值大于对照组(P<0.05);两组治疗前 CD3+、CD4+、CD4+/CD8+水平比较(P>0.05);观察组治疗前后CD3+、CD4+、CD4+/CD8+差值大于对照组(P<0.05).结论:采用NIV治疗可提高AECOPD合并高碳酸血症患者的临床治疗疗效,有效改善炎性因子指标与T淋巴细胞亚群,有助于促进患者全面康复.
Abstract
Objective:To analyze the clinical efficacy of non-invasive mechanical ventilation(NIV)in the treatment of AECOPD combined with hypercapnia and its effect on blood gas analysis,inflammation fac-tors.Methods:A retrospective analysis was conducted on 118 patients with AECOPD combined with hyper-capnia treated in our hospital from April 2022 to April 2023,58 cases were divided into control group(oxygen therapy and conventional drug treatment)and 60 cases were divided into observation group(NIV treatment).The clinical efficacy,blood gas analysis(pH,PaO2,PaCO2),Inflammatory factors(IL-6,IL-10,TNF-α)and T lymphocyte subsets(CD3+,CD4+,CD4+/CD8+).Results:The total effective rate of the control group(63.79%)was lower than that of the observation group(81.67%)(P<0.05);the differences in PaO2,pH,and PaCO2 before treatment between the two groups were not statistically significant(P>0.05).Com-parison of the differences in PaO2,pH,PaCO2 before and after treatment between the two groups(P>0.05);Comparison of the levels of IL-6,IL-10,TNF-α before treatment between the two groups(P>0.05);The difference in IL-6,IL-10,TNF-α before and after treatment in the observation group was greater than that in the control group(P<0.05);Comparison of the levels of CD3+,CD4+,CD4+/CD8+ before treatment between the two groups(P<0.05);Comparison of the levels of CD3+,CD4+,CD4+/CD8+ before treatment between the two groups(P<0.05).levels were compared(P>0.05);the difference between CD3+,CD4+,CD4+/CD8+ before and after treatment in the observation group was greater than that in the control group(P<0.05).Conclusion:NIV treatment improves the clinical therapeutic effect of AECOPD patients with hypercapnia,ef-fectively improves inflammatory factor indexes and T lymphocyte subsets,and contributes to the comprehensive recovery of patients.
维普
万方数据