Relationship between Serum IL-6 PCT and CRP Levels and Prognosis of Neonatal Sepsis
Objective:To investigate the relationship between serum interleukin-6(IL-6),procalcito-nin(PCT),and C-reactive protein(CRP)levels and the prognosis of neonatal sepsis.Methods:A total of 86 neonates with sepsis admitted to our hospital from August 2020 to March 2023 were enrolled as the study subjects.The general data of the cured/improved group and the death group were analyzed.The serum IL-6,PCT,and CRP levels of the neonates in the two groups at different time points were compared,and the factors affecting the prognosis of neonates with sepsis were analyzed.Results:Among the 86 neonates with sepsis,there were 77 neonates in the cured/improved group and 9 neonates in the death group(4 neonates died within 12 hours,2 died within 2 days,2 died within 3 days,and 1 died within 5 days).The percentages of IL-6>7 pg/mL,PCT>0.5 ng/mL,and CRP>10 mg/mL in the death group were higher than those in the cured/improved group at 12 hours,12-36 hours,and 7 days after onset(P<0.05).There were no statistically sig-nificant differences in gender,premature rupture of membranes,preterm birth,jaundice,and delivery method between the two groups(P>0.05).The gestational age,birth weight,and Ages&Stages Questionnaires(ASQ)at 0-6 years old were significantly different between the two groups(P<0.05).Multivariate logistic regression analysis showed that ASQ at 0-6 years old,IL-6,PCT,and CRP were independent risk factors for the prognosis of neonatal sepsis(P<0.001).Conclusion:Serum IL-6,PCT,and CRP levels are related factors affecting the prognosis of neonates with sepsis.Monitoring serum IL-6,PCT,and CRP levels may pro-vide reliable references for clinical adjustment of treatment strategies for neonatal sepsis.
万方数据
维普
