Relationship Between Expression of Ferroptosis-Related Indicators and Clinical Prognosis of Patients with Severe Acute Pancreatitis
Objective:To analyze the relationship between serum ferritin(SF)level,an indicator of ferroptosis,and the clinical prognosis of patients with severe acute pancreatitis(SAP).Methods:This study retrospectively analyzed 76 patients with SAP who were admitted to our hospital from January to December 2022.Serum SF levels were obtained on days 1,3,and 7 after admission,and patients were divided into two groups according to whether the serum SF level on day 1 was greater than 275 ng/mL:the elevated SF level group(n=36)and the normal SF level group(n=40).The correlation between SF level and CRP level,A-PACHE Ⅱ score,and CTSI score was analyzed,as well as its ability to predict SAP patients.Results:Com-pared with the normal SF level group,the elevated SF level group had significantly increased APACHE Ⅱ scores on days 1 and 7,CTSI score on day 7,SF levels on days 1,3,and 7,and mortality rate(P<0.05).The SF level on day 1 was significantly positively correlated with the APACHE Ⅱ scores on days 1 and 7,CTSI scores on days 1 and 7,and CRP level on day 7(r=0.236,0.495,0.269,0.582,0.362,respectively;all P<0.05).In Cox survival analysis,etiology,SF level on day 1,CTSI score on day 7,and persistent organ failure were independent risk factors for death in SAP patients(all P<0.05).ROC analysis showed that the SF level on day 1 of admission had the highest predictive ability for death in SAP patients(AUC=0.851),which was significantly higher than the APACHE Ⅱ score(AUC=0.630)and CTSI score(AUC=0.693)at the same time.Conclusion:Early elevated SF level is associated with poor prognosis of SAP and can be used as a potential predictor of death in patients.
万方数据
维普
