摘要
目的:分析铁死亡相关指标血清铁蛋白(SF)水平与重症胰腺炎(SAP)患者临床预后的关系.方法:本研究回顾性分析了2022 年1 月至 2022 年 12 月期间本院收治的 76 例SAP 患者.在住院后第1、3 和7 天获得血清SF水平,并根据第1 天血清SF水平是否大于275ng/mL将患者人群分为两组:SF水平升高组(n=36)和SF水平正常组(n=40).分析SF水平与CRP 水平、APACHEⅡ评分、CTSI评分的相关性,及其预测 SAP 患者的能力.结果:与 SF 水平正常组相比,SF 水平升高组第 1、7 天 A-PACHEⅡ评分、第7 天CTSI评分、第1、3、7 天SF水平和死亡率均显著增加(P<0.05).第1 天SF水平与第1、7 天APACHEⅡ评分,第1、7 天CTSI评分和第7 天CRP 水平呈显著正相关性(r=0.236、0.495、0.269、0.582、0.362,均P<0.05).在Cox生存分析中,病因、第1 天SF水平、第7 天CTSI评分、持续性器官衰竭是与SAP 患者死亡相关的独立影响因素(均P<0.05).ROC分析显示,入院第1 天SF水平对SAP 患者的死亡具有最高预测能力(AUC=0.851),显著高于同期的 APACHEⅡ评分(AUC=0.630)和CTSI评分(AUC=0.693).结论:早期SF水平升高与 SAP 不良预后有关,并可作为患者死亡的潜在预测因子.
Abstract
Objective:To analyze the relationship between serum ferritin(SF)level,an indicator of ferroptosis,and the clinical prognosis of patients with severe acute pancreatitis(SAP).Methods:This study retrospectively analyzed 76 patients with SAP who were admitted to our hospital from January to December 2022.Serum SF levels were obtained on days 1,3,and 7 after admission,and patients were divided into two groups according to whether the serum SF level on day 1 was greater than 275 ng/mL:the elevated SF level group(n=36)and the normal SF level group(n=40).The correlation between SF level and CRP level,A-PACHE Ⅱ score,and CTSI score was analyzed,as well as its ability to predict SAP patients.Results:Com-pared with the normal SF level group,the elevated SF level group had significantly increased APACHE Ⅱ scores on days 1 and 7,CTSI score on day 7,SF levels on days 1,3,and 7,and mortality rate(P<0.05).The SF level on day 1 was significantly positively correlated with the APACHE Ⅱ scores on days 1 and 7,CTSI scores on days 1 and 7,and CRP level on day 7(r=0.236,0.495,0.269,0.582,0.362,respectively;all P<0.05).In Cox survival analysis,etiology,SF level on day 1,CTSI score on day 7,and persistent organ failure were independent risk factors for death in SAP patients(all P<0.05).ROC analysis showed that the SF level on day 1 of admission had the highest predictive ability for death in SAP patients(AUC=0.851),which was significantly higher than the APACHE Ⅱ score(AUC=0.630)and CTSI score(AUC=0.693)at the same time.Conclusion:Early elevated SF level is associated with poor prognosis of SAP and can be used as a potential predictor of death in patients.
维普
万方数据