A Study on the Value of Combined Mid-Pregnancy Serum Freeβ-hCG and uE3 Screening for Severe Congenital Heart Disease in Pregnant Women Using the"Four-Plane"Method of Ultrasound
Objective:To investigate the clinical application value of the"four-plane"method of ultra-sound combined with mid-pregnancy maternal serum free human chorionic gonadotropin(Freeβ-hCG)and estriol(uE3)for screening severe congenital heart disease(CHD)in fetuses.Methods:A total of 97 preg-nant women who underwent mid-pregnancy CHD screening in our hospital from January 2020 to June 2021 were selected.The maternal serum Freeβ-hCG and uE3 levels were detected,and the"four-plane"method of ultrasound was used to screen for CHD.The diagnostic value of the"four-plane"method of ultrasound combined with serum Freeβ-hCG and uE3 levels for CHD was analyzed.Results:A total of 9 cases(9/97,9.28%)of severe CHD were confirmed by follow-up;25 cases of high-risk fetuses were detected by the"four-plane"method of ultrasound,of which 4 cases were confirmed to have severe CHD(4/25,16.00%);36 cases of high-risk fetuses were detected by maternal serum biochemical test,of which 6 cases were finally confirmed to have severe CHD(6/36,16.67%);and 9 cases of high-risk fetuses were detected by the com-bined"four-plane"method of ultrasound and maternal serum biochemical test,of which 5 cases were con-firmed to have severe CHD(5/9,55.56%).The sensitivity,specificity,accuracy,positive predictive value,and negative predictive value of the"four-plane"method of ultrasound for screening severe CHD were 16.00%,93.51%,74.51%,44.44%,and 77.22%,respectively.The sensitivity,specificity,accuracy,posi-tive predictive value,and negative predictive value of maternal serum Freeβ-hCG and uE3 levels for screening severe CHD were 55.56%,95.31%,92.08%,66.67%,and 64.00%,respectively.The sensitivity,speci-ficity,accuracy,positive predictive value,and negative predictive value of the combined screening for severe CHD were 55.56%,95.65%,92.08%,55.56%,and 91.09%,respectively.The diagnostic results of the combined detection were higher than those of the single detection method(P<0.05).Conclusion:The"four-plane"method of ultrasound has a high diagnostic value for screening severe CHD in pregnant women in mid-pregnancy.The combination of maternal serum Freeβ-hCG and uE3 levels can further improve the diagnostic accuracy and has good clinical application value.
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