Analysis of the Correlation between Coagulation and Fibrinolysis Imbalance and Inflammatory Indicators in Patients with Idiopathic Pulmonary Fibrosis and Respiratory Failure
Objective:To investigate the correlation between coagulation and fibrinolysis imbalance and inflammatory indicators in patients with idiopathic pulmonary fibrosis(IPF)and respiratory failure(RF).Methods:A total of 98 patients with IPF treated in our hospital from October 2020 to December 2023 were se-lected and divided into RF group(n=42)and non-RF group(n=56)based on whether they had RF.An automated coagulation analyzer was used to measure activated partial thromboplastin time(APTT),thrombin time(TT),prothrombin time(PT),and fibrinogen(FIB)levels;D-dimer(D-D)level was measured by immunoturbidimetry;neutrophil percentage(NEUT)and white blood cell count(WBC)were measured by automated blood cell analyzer;C-reactive protein(CRP)level was measured by enzyme-linked immunosor-bent assay(ELISA);and procalcitonin(PCT)level was measured by radioimmunoassay.The levels of coag-ulation and fibrinolysis indicators and inflammatory indicators in the two groups were compared;Pearson corre-lation analysis was used to analyze the correlation between coagulation and fibrinolysis indicators and inflamma-tory indicators;and the relationship between coagulation and fibrinolysis indicators and inflammatory indicators and IPF combined with RF was analyzed.Results:APTT,TT,and PT were lower in the RF group than in the non-RF group,while FIB and D-D were higher in the RF group than in the non-RF group,and the differ-ences were statistically significant(P<0.05).NEUT,WBC,CRP,and PCT levels were higher in the RF group than in the non-RF group,and the differences were statistically significant(P<0.05).Pearson correla-tion analysis showed that APTT,TT,and PT were negatively correlated with NEUT,WBC,CRP,and PCT,while FIB and D-D were positively correlated with NEUT,WBC,CRP,and PCT(P<0.05).APTT,TT,PT,FIB,D-D,NEUT,WBC,CRP and PCT were risk factors for IPF combined with RF.Conclusion:Pa-tients with IPF combined with RF have coagulation and fibrinolysis imbalance and inflammatory response,and coagulation and fibrinolysis imbalance is closely related to the changes in inflammatory indicators,which is worthy of clinical reference.
Coagulation and fibrinolysis systemIdiopathic pulmonary interstitial fibrosisRe-spiratory failureInflammatory indicators
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