Analysis of the Correlation between Levels of Lp-PLA2 LP(a) ApoB/ApoA-1 and the Severity and Prognosis of Acute Cerebral Infarction
Objective:To explore the correlation between the expression levels of lipoprotein-associated phospholipase A2(Lp-PLA2),lipoprotein a[LP(a)],apolipoprotein B(ApoB)/apolipoprotein A-1(ApoA-1)and the severity and prognosis of acute cerebral infarction(ACI).Methods:A total of 122 ACI patients admitted to our hospital from January 2022 to January 2023 were selected as the case group.Accord-ing to the severity of the disease,they were divided into mild(54 cases),moderate(49 cases),and severe(19 cases)groups.Another 97 healthy individuals who underwent physical examinations during the same peri-od were selected as the control group.According to the prognosis,the patients were divided into a good prog-nosis group(88 cases)and a poor prognosis group(34 cases).Differences in basic information and biochem-ical indicators between the case group and control group were compared,and the impact of the expression lev-els of Lp-PLA2,LP(a),and ApoB/ApoA-1 on the severity of the disease and prognosis was analyzed.Re-sults:The age,smoking history,number of hypertension cases,systolic blood pressure,LDL-C,LP(a),and Lp-PLA2 levels in the case group were higher than those in the control group(P<0.05),while the HDL-C level was lower in the case group than in the control group(P<0.05).Multivariate logistic regression a-nalysis indicated that age,smoking history,hypertension,systolic blood pressure,HDL-C,LDL-C,LP(a),Lp-PLA2,and ApoB/ApoA-1 were independent risk factors for ACI(P<0.05).The levels of Lp-PLA2,LP(a),and ApoB/ApoA-1 in the severe group were significantly higher than those in the mild and moderate groups(P<0.05),and the levels in the moderate group were significantly higher than those in the mild group(P<0.05).Spearman correlation analysis showed that the levels of Lp-PLA2,LP(a),and ApoB/ApoA-1 were positively correlated with the severity of the disease(r=0.796,0.718,0.451;P<0.05).The levels of Lp-PLA2,LP(a),and ApoB/ApoA-1 in the good prognosis group were significantly higher than those in the poor prognosis group(P<0.05).ROC curve analysis showed that the combined prediction AUC was 0.987.Conclusion:Elderly individuals,those with abnormal blood pressure and lipid levels,and those with poor lif-estyle habits are more prone to ACI.The levels of Lp-PLA2,ApoB/ApoA-1 are significantly correlated with the severity and prognosis of ACI.Monitoring these levels can effectively assess the progression of the patient's condition and has high clinical value.
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