Effects of Compound Matrine Injection Combined with Xihuang Pill on Cancer Pain and Fatigue Median Survival and Complication Rate in Patients with Advanced Colorectal Cancer Undergoing Palliative Care
Objective:To investigate the effects of compound Kushin injection combined with Xihuang Pill on cancer pain and fatigue,median survival and complication rate in patients with advanced colorectal cancer receiving palliative care.Methods:A total of 153 patients with advanced colorectal cancer treated in The First Affiliated Hospital of Chengdu Medical College from January 2020 to May 2021 were randomly divid-ed into control group(conventional palliative care),monotherapy group(conventional palliative care+Xi-huang pill)and combination group(conventional palliative care+Xihuang pill+compound matrine injec-tion),with 51 cases in each group.Cancer pain[numerical pain scale(NRS)],cancer fatigue[Piper Re-vised Fatigue Scale(PFS-R)],survival[Functional status score(KPS)],inflammatory factors[interleukin-6(IL-6),C-reactive protein(CRP),and IL-8,IL-1β],immune function(total T lymphocytes,total B lymphocytes,NK cells)were compared between the 3 groups before treatment,1 cycle and 3 cycles after treatment,and the tumor control effect,complications,toxicity and median survival of the 3 groups were com-pared.Results:The proportion of stable tumor in combination group was higher than that in control group and monotherapy group,and the proportion of progressive patients was lower than that in monotherapy group and control group,and the proportion of patients in monotherapy group was lower than that in control group(P<0.05).After 1 and 3 cycles of treatment,the NRS score and PFS-R score in combination group were lower than those in monotherapy group and control group,and the monotherapy group was lower than that in control group,and the KPS score was higher than that in monotherapy group and control group,and the monotherapy group was higher than that in control group(P<0.05).After 1 and 3 cycles of treatment,the total T lympho-cytes,total B lymphocytes and NK cells in combination group were higher than those in monotherapy group and control group,and monotherapy group was higher than control group(P<0.05).The levels of IL-6,CRP,IL-8 and IL-1β in combination group were lower than those in monotherapy group and control group af-ter 1 and 3 cycles of treatment,and those in monotherapy group were lower than those in control group(P<0.05).The incidence of constipation,insomnia,intestinal obstruction,intestinal bleeding,hypothermia and in-fection in combination group was lower than that in monotherapy group and control group,and the incidence of constipation,insomnia,intestinal obstruction,hypothermia and infection in drug group was lower than that in control group(P<0.05).The incidence of nausea,vomiting and myelosuppression in combination group was lower than that in monotherapy group and control group,and the incidence in monotherapy group was lower than that in control group(P<0.05).After 2 years of follow-up,2 cases were lost to follow-up,7 cases died in the combination group,20 cases died in the monotherapy group,and 34 cases died in the control group.The median survival time of combination group,single drug group and control group was 18,14 and 13 months,respectively,and the median survival time of combination group was longer than that of monotherapy group and control group(P<0.05).Conclusion:Compound matrine injection combined with Xihuang Pill ef-fectively alleviated cancer pain and fatigue,improve the quality of life,enhance immune function,reduce in-flammatory response and complication rate in patients with advanced colorectal cancer in palliative care.
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