Correlation of Serum ICAM-1 Hcy and MCP-1 Levels with Vascular Endothelial Function in Patients with Retinal Vein Occlusion
Objective:To investigate the correlation between serum intercellular adhesion molecule-1(ICAM-1),Homocysteine(Hcy),and Monocyte chemotactic protein-1(MCP-1)levels and vascular en-dothelial function in patients with retinal vein occlusion(RVO).Methods:A retrospective,double-blind method was used to analyze 95 patients with RVO admitted to our hospital from July 2020 to October 2023 as the RVO group,and 102 healthy people who underwent a physical examination in our hospital during the same period were selected as the normal control group.To compare the levels of ICAM-1,Hcy,MCP-1,vascular endothelial function[Endothelin-1(ET-1),nitric oxide(NO)]between the two groups;to compare the levels of ICAM-1,Hcy,MCP-1,ET-1 and NO in the RVO group with different types of diseases;to com-pare the levels of ICAM-1,MCP-1,ET-1 and NO in the RVO group with different degrees of diseases;and to analyze the correlation between serum levels of ICAM-1,Hcy,MCP-1 and vascular endothelial function in RVO patients.Results:Serum ICAM-1,Hcy,MCP-1,and ET-1 levels were higher and NO levels were lower in the RVO group than in the control group(P<0.05);serum ICAM-1,Hcy,MCP-1,and ET-1 lev-els were higher and NO levels were lower in the CRVO patients than in the BRVO patients(P<0.05);ICAM-1,MCP-1,and ET 1levels:mild<moderate<severe,NO levels:mild>moderate>severe(P<0.05);serum ICAM-1,Hcy,MCP-1 levels were positively correlated with ET-1 levels and negatively correlated with NO levels(P<0.05).Conclusion:Serum ICAM-1,Hcy and MCP-1 levels are all abnormally elevated in RVO patients,and are correlated with ET-1 and NO to a certain extent.Detection of serum ICAM-1,Hcy and MCP-1 levels can be used to assess the status of vascular endothelial function injury,to facilitate early treat-ment.
Retinal vein occlusionICAM-1HcyMCP-1Vascular endothelial function
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