The Value of miR-200c and PAPP-A Levels Combined with Transvaginal Ultrasound in Differentiating Threatened Abortion and Ectopic Pregnancy
Objective:To explore the value of serum miR-200c and pregnancy-associated plasma pro-tein-A(PAPP-A)levels in combination with transvaginal ultrasound for the differential diagnosis of threat-ened abortion and ectopic pregnancy.Methods:This study was conducted from January 2020 to January 2022,including 43 cases of normal early pregnancy,43 cases of ectopic pregnancy,and 43 cases of threat-ened abortion who visited our hospital during this period.All patients underwent transvaginal ultrasound exam-ination,and various ultrasound parameters were recorded.The differences in serum miR-200c and PAPP-A levels at the time of consultation were compared among the groups to investigate their diagnostic value for threatened abortion and ectopic pregnancy.Results:There was no statistically significant difference in the av-erage diameter of the corpus luteum among the three groups(P>0.05).The endometrial thickness in the ec-topic pregnancy group was lower than that in the threatened abortion and normal early pregnancy groups,and the thickness in the threatened abortion group was lower than that in the normal early pregnancy group(P<0.05).The resistance index(RI)in the threatened abortion group was higher than that in the ectopic pregnancy and normal early pregnancy groups,and the RI in the ectopic pregnancy group was higher than that in the nor-mal early pregnancy group(P<0.05).The peak systolic velocity(PSV)in both the threatened abortion and ectopic pregnancy groups was lower than that in the normal early pregnancy group(P<0.05),but there was no statistically significant difference between the threatened abortion and ectopic pregnancy groups(P>0.05).The serum miR-200c levels in the threatened abortion and ectopic pregnancy groups were higher than those in the normal early pregnancy group(P<0.05),but there was no statistically significant difference be-tween the threatened abortion and ectopic pregnancy groups(P>0.05).The PAPP-A levels in the ectopic pregnancy group were lower than those in the threatened abortion and normal early pregnancy groups,and the levels in the threatened abortion group were lower than those in the normal early pregnancy group(P<0.05).Analysis showed that the specificity of combined ultrasound,miR-200c,and PAPP-A levels for diagnosing threatened abortion was higher than that of any single indicator,and the specificity and positive predictive val-ue for diagnosing ectopic pregnancy were higher than those of any single indicator.Conclusion:The combina-tion of serum miR-200c and PAPP-A levels with transvaginal ultrasound examination can effectively differen-tiate between threatened abortion and ectopic pregnancy,improving diagnostic accuracy and specificity,with significant clinical application potential.
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